Flavonoids activate pregnane x receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cells
about
Evaluation of the toxicity of Pradosia huberi extract during the preimplantation in Wistar ratsDevelopment of BODIPY FL vindoline as a novel and high-affinity pregnane X receptor fluorescent probe.PXR antagonists and implication in drug metabolism.Role of CAR and PXR in xenobiotic sensing and metabolism.Novel yeast-based strategy unveils antagonist binding regions on the nuclear xenobiotic receptor PXRPiperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1In vitro Effects of Four Native Brazilian Medicinal Plants in CYP3A4 mRNA Gene Expression, Glutathione Levels, and P-Glycoprotein ActivityFlavonoids as dietary regulators of nuclear receptor activityA vinblastine fluorescent probe for pregnane X receptor in a time-resolved fluorescence resonance energy transfer assay.Identification and characterization of phosphorylation sites within the pregnane X receptor protein.Stability of the human pregnane X receptor is regulated by E3 ligase UBR5 and serine/threonine kinase DYRK2.Cell signaling and receptors with resorcinols and flavonoids: redox, reactive oxygen species, and physiological effects.The evolution of our understanding of endo-xenobiotic crosstalk and cytochrome P450 regulation and the therapeutic implications.Post-translational and post-transcriptional modifications of pregnane X receptor (PXR) in regulation of the cytochrome P450 superfamily.Interference of flavonoids with fluorescent intracellular probes: methodological implications in the evaluation of the oxidative burst by flow cytometry.Cancer chemoprevention through dietary flavonoids: what's limiting?Mechanisms of xenobiotic receptor activation: Direct vs. indirect.The regulation of human hepatic drug transporter expression by activation of xenobiotic-sensing nuclear receptors.Analysis of flavonoids regulating the expression of UGT1A1 via xenobiotic receptors in intestinal epithelial cells.Rotenone-induced oxidative stress and apoptosis in human liver HepG2 cells.UBC and YWHAZ as suitable reference genes for accurate normalisation of gene expression using MCF7, HCT116 and HepG2 cell lines.Intraperitoneal administration of apigenin in liver ischemia/reperfusion injury protective effects.U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells.A Molecular Aspect in the Regulation of Drug Metabolism: Does PXR-Induced Enzyme Expression Always Lead to Functional Changes in Drug Metabolism?Effects in rats of maternal exposure to raspberry leaf and its constituents on the activity of cytochrome p450 enzymes in the offspring.Potential of rooibos, its major C-glucosyl flavonoids, and Z-2-(β-D-glucopyranosyloxy)-3-phenylpropenoic acid in prevention of metabolic syndrome.Is a flavonoid-rich diet with steamer cooking safe during calcineurin inhibitors therapy?"Drugs on oxygen": an update and perspective on the role of cytochrome P450 testing in pharmacology.The Potential and Action Mechanism of Polyphenols in the Treatment of Liver Diseases.Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavones.
P2860
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P2860
Flavonoids activate pregnane x receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cells
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Flavonoids activate pregnane x ...... in HepG2 liver carcinoma cells
@ast
Flavonoids activate pregnane x ...... in HepG2 liver carcinoma cells
@en
type
label
Flavonoids activate pregnane x ...... in HepG2 liver carcinoma cells
@ast
Flavonoids activate pregnane x ...... in HepG2 liver carcinoma cells
@en
prefLabel
Flavonoids activate pregnane x ...... in HepG2 liver carcinoma cells
@ast
Flavonoids activate pregnane x ...... in HepG2 liver carcinoma cells
@en
P2093
P2860
P356
P1433
P1476
Flavonoids activate pregnane x ...... in HepG2 liver carcinoma cells
@en
P2093
Hanqing Dong
Taosheng Chen
Wenwei Lin
P2860
P2888
P356
10.1186/1471-2091-11-23
P577
2010-06-16T00:00:00Z
P5875
P6179
1046700745