U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells.
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Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator InteractionsThe pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 coactivator2-Chloroethanol Induced Upregulation of Matrix Metalloproteinase-2 in Primary Cultured Rat Astrocytes Via MAPK Signal Pathways.Upregulation of Matrix Metalloproteinase-9 in Primary Cultured Rat Astrocytes Induced by 2-Chloroethanol Via MAPK Signal PathwaysCommentary: Usage of Mitogen-Activated Protein Kinase Small Molecule Inhibitors: More Than Just Inhibition!
P2860
U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells.
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2014 nî lūn-bûn
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年论文
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2014年论文
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2014年论文
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name
U0126, a mitogen-activated pro ...... receptor (PXR) in HepG2 cells.
@en
type
label
U0126, a mitogen-activated pro ...... receptor (PXR) in HepG2 cells.
@en
prefLabel
U0126, a mitogen-activated pro ...... receptor (PXR) in HepG2 cells.
@en
P2093
P2860
P50
P1476
U0126, a mitogen-activated pro ...... receptor (PXR) in HepG2 cells
@en
P2093
Michaela Dubecka
Michal Bitman
Michal Urban
Radim Vrzal
P2860
P2888
P304
P356
10.1007/S00204-014-1254-2
P577
2014-05-14T00:00:00Z