Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator - Wikidata - awgldk - TriplyDB

Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator

Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator

http://www.wikidata.org/entity/Q33606444

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A critical review of perfluorooctanoate and perfluorooctanesulfonate exposure and immunological health conditions in humans Critical role of toxicologic pathology in a short-term screen for carcinogenicity Scientific and Regulatory Policy Committee (SRPC) Review: Interpretation and Use of Cell Proliferation Data in Cancer Risk Assessment.Phenobarbital and propiconazole toxicogenomic profiles in mice show major similarities consistent with the key role that constitutive androstane receptor (CAR) activation plays in their mode of action Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium Small-molecule modulators of the constitutive androstane receptor.Small-molecule modulators of PXR and CAR.RNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome.Genome-wide analysis of human constitutive androstane receptor (CAR) transcriptome in wild-type and CAR-knockout HepaRG cells Activation of the Constitutive Androstane Receptor Increases the Therapeutic Index of CHOP in Lymphoma Treatment A critical review of perfluorooctanoate and perfluorooctanesulfonate exposure and cancer risk in humans.Human relevance framework for rodent liver tumors induced by the insecticide sulfoxaflor.Mode of action analysis for pesticide-induced rodent liver tumours involving activation of the constitutive androstane receptor: relevance to human cancer risk.The use of mode of action information in risk assessment: quantitative key events/dose-response framework for modeling the dose-response for key events.A critical assessment of the methodologies to investigate the role of inhibition of apoptosis in rodent hepatocarcinogenesis.Contribution of new technologies to characterization and prediction of adverse effects.Risk assessments for chronic exposure of children and prospective parents to ethylbenzene (CAS No. 100-41-4).Role of nonalcoholic fatty liver disease as risk factor for drug-induced hepatotoxicity.PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling.Mode of action analysis for rat hepatocellular tumors produced by the synthetic pyrethroid momfluorothrin: evidence for activation of the constitutive androstane receptor (CAR) and mitogenicity in rat hepatocytes.Dose-response analysis of epigenetic, metabolic, and apical endpoints after short-term exposure to experimental hepatotoxicants.An Evaluation of the Human Relevance of the Lung Tumors Observed in Female Mice Treated With Permethrin Based on Mode of Action.Hepatotoxic effects of cyproconazole and prochloraz in wild-type and hCAR/hPXR mice.Origin of the TTC values for compounds that are genotoxic and/or carcinogenic and an approach for their re-evaluation.Pathway Based Toxicology and Fit-for-Purpose Assays.Relationship of Metabolism and Cell Proliferation to the Mode of Action of Fluensulfone-Induced Mouse Lung Tumors. II: Additional Mechanistic Studies.Tumor promotion and inhibition by phenobarbital in livers of conditional Apc-deficient mice.Role of CYP2B in Phenobarbital-Induced Hepatocyte Proliferation in Mice.Exposure to perfluoroundecanoic acid (PFUnDA) accelerates insulitis development in a mouse model of type 1 diabetes.From the Cover: Three-Dimensional (3D) HepaRG Spheroid Model With Physiologically Relevant Xenobiotic Metabolism Competence and Hepatocyte Functionality for Liver Toxicity Screening.Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development.Dose and Effect Thresholds for Early Key Events in a PPARα-Mediated Mode of Action.Mechanistic Investigation of Toxaphene Induced Mouse Liver Tumors.Human hepatocytes support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogen sodium phenobarbital in an in vivo study using a chimeric mouse with humanized liver.Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors.Dose-response modeling of early molecular and cellular key events in the CAR-mediated hepatocarcinogenesis pathway.Integration of novel approaches demonstrates simultaneous metabolic inactivation and CAR-mediated hepatocarcinogenesis of a nitrification inhibitor.Sedaxane-Use of Nuclear Receptor Transactivation Assays, Toxicogenomics, and Toxicokinetics as Part of a Mode of Action Framework for Rodent Liver Tumors.Superoxide deficiency attenuates promotion of hepatocarcinogenesis by cytotoxicity in NADPH oxidase knockout mice.Interleukin-6 Induces DEC1, Promotes DEC1 Interaction with RXRα and Suppresses the Expression of PXR, CAR and Their Target Genes.

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Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator

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Critical Reviews in Toxicology

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P2860

Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital

Phenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signaling

Long-term administration of DDT or phenobarbital-Na in Wistar rats

The histology and development of hepatic nodules and carcinoma in C3H/He and C57BL/6 mice following chronic phenobarbitone administration

Non-carcinogenicity, but dose-related increase in preneoplastic hepatocellular lesions, in a two-year feeding study of phenobarbital sodium in male F344 rats

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

The effect of phenobarbital on the methylation level of the p16 promoter region in rat liver

A review of epidemiological data on epilepsy, phenobarbital, and risk of liver cancer.

Lack of phenobarbital-mediated promotion of hepatocarcinogenesis in connexin32-null mice.

A data-based assessment of alternative strategies for identification of potential human cancer hazards.

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