B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans. - Wikidata - awgldk - TriplyDB

B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans.

B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans.

http://www.wikidata.org/entity/Q33615168

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DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation Elucidation of seventeen human peripheral blood B-cell subsets and quantification of the tetanus response using a density-based method for the automated identification of cell populations in multidimensional flow cytometry data High levels of Crohn's disease-associated anti-microbial antibodies are present and independent of colitis in chronic granulomatous disease A Central Role for STAT3 in Gammaherpesvirus-Life Cycle and -Diseases Primary immunodeficiencies associated with eosinophilia IL-21 Signaling in Immunity A brief history of T cell help to B cells Inborn errors of human STAT1: allelic heterogeneity governs the diversity of immunological and infectious phenotypes STAT3 and the Hyper-IgE syndrome: Clinical presentation, genetic origin, pathogenesis, novel findings and remaining uncertainties Activation of B cells by non-canonical helper signals The role of interleukin-21 in HIV infection Factors regulating immunoglobulin production by normal and disease-associated plasma cells Cancers Related to Immunodeficiencies: Update and Perspectives The Biological Effects of IL-21 Signaling on B-Cell-Mediated Responses in Organ Transplantation Primary immunodeficiency update: Part I. Syndromes associated with eczematous dermatitis B cell-helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen The Hyper-IgE Syndromes: Lessons in Nature, From Bench to Bedside Efficacy of gene therapy for X-linked severe combined immunodeficiency Gene Therapy for X-Linked Severe Combined Immunodeficiency: Where Do We Stand?HIV-1 and SIV Predominantly Use CCR5 Expressed on a Precursor Population to Establish Infection in T Follicular Helper Cells.Human herpesvirus-8 infection leads to expansion of the preimmune/natural effector B cell compartment.Mycophenolic acid counteracts B cell proliferation and plasmablast formation in patients with systemic lupus erythematosus IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation.PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells New insights into Blimp-1 in T lymphocytes: a divergent regulator of cell destiny and effector function.Interleukin-21: a new mediator of inflammation in systemic lupus erythematosus.The dysfunction of T follicular helper cells Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency Gene therapy for inherited immunodeficiency.Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells.Early preservation of CXCR5+ PD-1+ helper T cells and B cell activation predict the breadth of neutralizing antibody responses in chronic HIV-1 infection.Innate signaling networks in mucosal IgA class switching An HIV-1 envelope glycoprotein trimer with an embedded IL-21 domain activates human B cells CD4 T Cells Mediate Both Positive and Negative Regulation of the Immune Response to HIV Infection: Complex Role of T Follicular Helper Cells and Regulatory T Cells in Pathogenesis STAT3 signaling induces the differentiation of human ICOS(+) CD4 T cells helping B lymphocytes.Attenuation of HIV-associated human B cell exhaustion by siRNA downregulation of inhibitory receptors Upregulation of IL-21 receptor on B cells and IL-21 secretion distinguishes novel 2009 H1N1 vaccine responders from nonresponders among HIV-infected persons on combination antiretroviral therapy.Loss of memory B cells during chronic HIV infection is driven by Foxo3a- and TRAIL-mediated apoptosis.A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory.Interleukin-21 administration to rhesus macaques chronically infected with simian immunodeficiency virus increases cytotoxic effector molecules in T cells and NK cells and enhances B cell function without increasing immune activation or viral replic

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P2860

B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans.

http://www.wikidata.org/entity/Q33615168

description

2010 nî lūn-bûn

@nan

2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

B cell-intrinsic signaling thr ...... antibody responses in humans.

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B cell-intrinsic signaling thr ...... antibody responses in humans.

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type

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B cell-intrinsic signaling thr ...... antibody responses in humans.

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B cell-intrinsic signaling thr ...... antibody responses in humans.

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B cell-intrinsic signaling thr ...... antibody responses in humans.

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B cell-intrinsic signaling thr ...... antibody responses in humans.

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P1433

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Journal of Experimental Medicine

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B cell-intrinsic signaling thr ...... antibody responses in humans.

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P2093

D Sean Riminton

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Dan Engelhard

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Danielle T Avery

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David A Fulcher

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Gary Y Chew

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Jane Peake

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Joachim Roesler

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Karl E Bleasel

http://www.w3.org/2001/XMLSchema#string

Klaus Magdorf

http://www.w3.org/2001/XMLSchema#string

Matthew C Cook

http://www.w3.org/2001/XMLSchema#string

P2860

Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes

Selective generation of functional somatically mutated IgM+CD27+, but not Ig isotype-switched, memory B cells in X-linked lymphoproliferative disease

Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching

Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages

B cell differentiation and isotype switching is related to division cycle number

Characterization of IL-4 and IL-13 signals dependent on the human IL-13 receptor alpha chain 1: redundancy of requirement of tyrosine residue for STAT3 activation

Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex

The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3

A critical role for IL-21 in regulating immunoglobulin production

DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL

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155-171

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scholarly article

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10.1084/JEM.20091706

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1

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207

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Jean-Laurent Casanova

Elissa K. Deenick

Peter D Arkwright

Stephanie Boisson-Dupuis

Jacinta Bustamante

Martyn A. French

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2010-01-04T00:00:00Z

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40847173

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20048285

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2812540

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