about
DOCK8 deficiency impairs CD8 T cell survival and function in humans and miceSelective generation of functional somatically mutated IgM+CD27+, but not Ig isotype-switched, memory B cells in X-linked lymphoproliferative diseaseHuman TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndromeB cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans.IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells.Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules.STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and functionExpansion of somatically reverted memory CD8+ T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus.Functional STAT3 deficiency compromises the generation of human T follicular helper cells.Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling.IMMUNODEFICIENCIES. Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations.Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets.DOCK8 is critical for the survival and function of NKT cellsSignal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8(+) T-cell memory formation and function.A recurrent dominant negative E47 mutation causes agammaglobulinemia and BCR(-) B cells.Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficienciesNaive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells.Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations.IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts.The role of SAP and SLAM family molecules in the humoral immune response.Regulation of T follicular helper cell formation and function by antigen presenting cells.The regulation and role of T follicular helper cells in immunity.T cell-B cell interactions in primary immunodeficiencies.The good, the bad and the ugly - TFH cells in human health and disease.Human T follicular helper (Tfh) cells and disease.STAT3 is a central regulator of lymphocyte differentiation and function.Human T follicular helper cells in primary immunodeficiencies.Human T Follicular Helper Cells in Primary Immunodeficiency: Quality Just as Important as Quantity.IL-27 Directly Enhances Germinal Center B Cell Activity and Potentiates Lupus in Sanroque Mice.Here, there and everywhere: T follicular helper cells on the move.Cytokine-Mediated Regulation of Human Lymphocyte Development and Function: Insights from Primary Immunodeficiencies.DOCK8 Drives Src-Dependent NK Cell Effector Function.Dedicator of cytokinesis 8-deficient CD4+ T cells are biased to a TH2 effector fate at the expense of TH1 and TH17 cells.Immunology: Cytotoxic T cells that escape exhaustion.FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production.Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure.The circulating life of a memory T-follicular helper cell.Epstein-Barr virus persistence in the absence of conventional memory B cells: IgM+IgD+CD27+ B cells harbor the virus in X-linked lymphoproliferative disease patients.Automatic generation of lymphocyte heterogeneity: Division-dependent changes in the expression of CD27, CCR7 and CD45 by activated human naive CD4+ T cells are independently regulated.
P50
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description
hulumtuese
@sq
onderzoeker
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researcher
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հետազոտող
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name
Cindy S Ma
@ast
Cindy S Ma
@en
Cindy S Ma
@es
Cindy S Ma
@nl
Cindy S Ma
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type
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Cindy S Ma
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Cindy S Ma
@en
Cindy S Ma
@es
Cindy S Ma
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Cindy S Ma
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prefLabel
Cindy S Ma
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Cindy S Ma
@en
Cindy S Ma
@es
Cindy S Ma
@nl
Cindy S Ma
@sl
P106
P21
P31
P496
0000-0001-5387-8413