A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate. - Wikidata - awgldk - TriplyDB

A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate.

A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate.

http://www.wikidata.org/entity/Q33620076

about

A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase Insulin-Sensitizers, Polycystic Ovary Syndrome and Gynaecological Cancer Risk PKCη/Rdx-driven phosphorylation of PDK1: a novel mechanism promoting cancer cell survival and permissiveness for parvovirus-induced lysis Novel inhibitors of AKT: assessment of a different approach targeting the pleckstrin homology domain.Small-molecule inhibitors of the PI3K signaling network Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance.Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB.Animal models as tools to investigate antidiabetic and anti-inflammatory plants.3-phosphoinositide-dependent kinase 1 controls breast tumor growth in a kinase-dependent but Akt-independent manner.Inositol pyrophosphates as mammalian cell signals 3-Phosphoinositide-dependent protein kinase-1 as an emerging target in the management of breast cancer.The "Other" Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances in myo-Inositol Chemistry).CS2164, a novel multi-target inhibitor against tumor angiogenesis, mitosis and chronic inflammation with anti-tumor potency.Ovarian cancer molecular pathology.PDK1 inhibitors Emerging role of the KRAS-PDK1 axis in pancreatic cancer.Cellular internalisation of an inositol phosphate visualised by using fluorescent InsP5 Synthesis and antitumor activity of inositol phosphotriester analogues.Regioselective opening of myo-inositol orthoesters: mechanism and synthetic utility.KCS1 deletion in Saccharomyces cerevisiae leads to a defect in translocation of autophagic proteins and reduces autophagosome formation.Targeting PDK1 for Chemosensitization of Cancer Cells.Chemoselective alcoholysis/acetolysis of trans-ketals over cis-ketals and its application in the total synthesis of the cellular second messenger, D-myo-inositol-1,4,5-trisphosphate.

P2860

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P2860

A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate.

http://www.wikidata.org/entity/Q33620076

description

2010 nî lūn-bûn

@nan

2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

A novel inhibitor of the PI3K/ ...... l 1,3,4,5,6-pentakisphosphate.

@ast

A novel inhibitor of the PI3K/ ...... l 1,3,4,5,6-pentakisphosphate.

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type

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A novel inhibitor of the PI3K/ ...... l 1,3,4,5,6-pentakisphosphate.

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A novel inhibitor of the PI3K/ ...... l 1,3,4,5,6-pentakisphosphate.

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prefLabel

A novel inhibitor of the PI3K/ ...... l 1,3,4,5,6-pentakisphosphate.

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British Journal of Cancer

P1476

A novel inhibitor of the PI3K/ ...... l 1,3,4,5,6-pentakisphosphate.

@en

P2093

A M Riley

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B V L Potter

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D Chiozzotto

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H Y Godage

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M Broggini

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M Falasca

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M Mazzoletti

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S Previdi

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T Maffucci

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P2860

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms

AKT/PKB signaling: navigating downstream

mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice

Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate

Novel inositol phospholipid headgroup surrogate crystallized in the pleckstrin homology domain of protein kinase Balpha

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance

TOR signaling in growth and metabolism

P2888

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104-114

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scholarly article

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10.1038/SJ.BJC.6605408

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1

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102

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1027851086

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20051961

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2813745

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