New concepts in immunology relevant to idiosyncratic drug reactions: the "danger hypothesis" and innate immune system.
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Payload drug vs. nanocarrier biodegradation by myeloperoxidase- and peroxynitrite-mediated oxidations: pharmacokinetic implicationsCase Characterization, Clinical Features and Risk Factors in Drug-Induced Liver InjuryContributions of nonhematopoietic cells and mediators to immune responses: implications for immunotoxicologyBioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity In VitroHow to report and discuss ADME data in medicinal chemistry publications: in vitro data or in vivo extrapolations?Relationships Between Pharmacovigilance, Molecular, Structural, and Pathway Data: Revealing Mechanisms for Immune-Mediated Drug-Induced Liver Injury.Patients with quinine-induced immune thrombocytopenia have both "drug-dependent" and "drug-specific" antibodies.Idiosyncratic reactions: new methods of identifying high-risk patients.Idiosyncratic drug-induced liver injury and the role of inflammatory stress with an emphasis on an animal model of trovafloxacin hepatotoxicitySafety and tolerability of antiepileptic drug treatment in children with epilepsy.Immunological principles of T-cell-mediated adverse drug reactions in skin.Screening and characterization of reactive compounds with in vitro peptide-trapping and liquid chromatography/high-resolution accurate mass spectrometry.N-oxidation of drugs associated with idiosyncratic drug reactions.Serum acute phase reactants hallmark healthy individuals at risk for acetaminophen-induced liver injury.Risk factors for idiosyncratic drug-induced liver injury.ORAL ADVERSE DRUG REACTIONS TO CARDIOVASCULAR DRUGS.Cytotoxic Synergy Between Cytokines and NSAIDs Associated With Idiosyncratic Hepatotoxicity Is Driven by Mitogen-Activated Protein KinasesRole of metabolism in drug-induced idiosyncratic hepatotoxicity.Cytochrome P450s and other enzymes in drug metabolism and toxicity.Role of animal models in the study of drug-induced hypersensitivity reactionsImmune response to xenobiotics in the skin: from contact sensitivity to drug allergy.Minimising the potential for metabolic activation in drug discovery.Idiosyncratic adverse reactions to antiepileptic drugs.Toxicological significance of mechanism-based inactivation of cytochrome p450 enzymes by drugs.Molecular mechanisms underlying chemical liver injury.Immune mediation of hypersensitivity adverse drug reactions: implications for therapy.Metabolic bioactivation and drug-related adverse effects: current status and future directions from a pharmaceutical research perspective.Mechanisms of drug toxicity and relevance to pharmaceutical development.Challenges and solutions to metabolites in safety testing: impact of the International Conference on Harmonization M3(R2) guidance.Drug-induced autoimmune-like hepatitis.Review article: Drug-induced liver injury--its pathophysiology and evolving diagnostic tools.Educational case series: Mechanisms of drug allergy.Role of immune reactions in drug-induced liver injury (DILI).The generation, detection, and effects of reactive drug metabolites.Drug-induced liver injury: the role of drug metabolism and transport.Recent advances in irreversible kinase inhibitors.Formation of reactive metabolites and management of tyrosine kinase inhibitor-induced hepatotoxicity: a literature review.Current understanding of the mechanisms of idiosyncratic drug-induced agranulocytosis.Profiling cumulative proportional reporting ratios of drug-induced liver injury in the FDA Adverse Event Reporting System (FAERS) database.Detecting reactive drug metabolites for reducing the potential for drug toxicity.
P2860
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P2860
New concepts in immunology relevant to idiosyncratic drug reactions: the "danger hypothesis" and innate immune system.
description
1999 nî lūn-bûn
@nan
1999 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
New concepts in immunology rel ...... sis" and innate immune system.
@ast
New concepts in immunology rel ...... sis" and innate immune system.
@en
type
label
New concepts in immunology rel ...... sis" and innate immune system.
@ast
New concepts in immunology rel ...... sis" and innate immune system.
@en
prefLabel
New concepts in immunology rel ...... sis" and innate immune system.
@ast
New concepts in immunology rel ...... sis" and innate immune system.
@en
P356
P1476
New concepts in immunology rel ...... sis" and innate immune system.
@en
P2093
Uetrecht JP
P304
P356
10.1021/TX980249I
P577
1999-05-01T00:00:00Z