Different susceptibility to the Parkinson's toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1 - Wikidata - awgldk - TriplyDB

Different susceptibility to the Parkinson's toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1

Different susceptibility to the Parkinson's toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1

http://www.wikidata.org/entity/Q33646741

about

Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics The Nrf2-ARE pathway: a valuable therapeutic target for the treatment of neurodegenerative diseases The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive?Binding mode and structure-activity relationships around direct inhibitors of the Nrf2-Keap1 complex Isothiocyanates Are Promising Compounds against Oxidative Stress, Neuroinflammation and Cell Death that May Benefit Neurodegeneration in Parkinson's Disease Serotonin 1A Receptors on Astrocytes as a Potential Target for the Treatment of Parkinson's Disease The complexity of the Nrf2 pathway: beyond the antioxidant response Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection NRF2-regulation in brain health and disease: implication of cerebral inflammation Temporal and spatial dynamics of nrf2-antioxidant response elements mediated gene targets in cortex and hippocampus after controlled cortical impact traumatic brain injury in mice.Role of the Keap1/Nrf2 pathway in neurodegenerative diseases.The endotoxin-induced neuroinflammation model of Parkinson's disease.Absence of Nrf2 or its selective overexpression in neurons and muscle does not affect survival in ALS-linked mutant hSOD1 mouse models.PEP-1-HO-1 prevents MPTP-induced degeneration of dopaminergic neurons in a Parkinson's disease mouse model.A novel compound VSC2 has anti-inflammatory and antioxidant properties in microglia and in Parkinson's disease animal model.Increased Alzheimer's disease-like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy Altered behavioral development in Nrf2 knockout mice following early postnatal exposure to valproic acid.Comprehensive assessment of genetic sequence variants in the antioxidant 'master regulator' NRF2 in idiopathic Parkinson's disease.A novel synthetic isothiocyanate ITC-57 displays antioxidant, anti-inflammatory, and neuroprotective properties in a mouse Parkinson's disease model.Administration of the Nrf2-ARE activators sulforaphane and carnosic acid attenuates 4-hydroxy-2-nonenal-induced mitochondrial dysfunction ex vivo.Nrf2--a therapeutic target for the treatment of neurodegenerative diseases.Antioxidant gene therapy against neuronal cell death.Modulation of Nrf2/ARE pathway by food polyphenols: a nutritional neuroprotective strategy for cognitive and neurodegenerative disorders Metallobiology of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity.Carbon monoxide and the CNS: challenges and achievements.The emerging role of Nrf2 in mitochondrial function Potential repositioning of exemestane as a neuroprotective agent for Parkinson's disease.Microglia antioxidant systems and redox signalling.New melatonin-cinnamate hybrids as multi-target drugs for neurodegenerative diseases: Nrf2-induction, antioxidant effect and neuroprotection.Activating transcription factor 3 and the nervous system.Are Astrocytes the Predominant Cell Type for Activation of Nrf2 in Aging and Neurodegeneration?Nrf2 regulates ROS production by mitochondria and NADPH oxidase Alleviation of Oxidative Damage and Involvement of Nrf2-ARE Pathway in Mesodopaminergic System and Hippocampus of Status Epilepticus Rats Pretreated by Intranasal Pentoxifylline.The Nrf2/ARE Pathway: A Promising Target to Counteract Mitochondrial Dysfunction in Parkinson's Disease.Molecular mechanism underlying the cerebral effect of Gly-Pro-Glu tripeptide bound to L-dopa in a Parkinson's animal model.Paraquat and MPTP induce neurodegeneration and alteration in the expression profile of microRNAs: the role of transcription factor Nrf2.Curcumin prevents maleate-induced nephrotoxicity: relation to hemodynamic alterations, oxidative stress, mitochondrial oxygen consumption and activity of respiratory complex I.Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system.

P2860

Q26751266-2AE43367-E40E-427A-8D8E-FE96F7841BBA Q26778368-F5FB7622-6862-4334-A016-E905582CA294 Q26822972-00C8EBA0-A818-48F0-9774-51B2C15275AA Q26861263-841CE14D-AC1A-4516-BDB0-6C245DDAC0A8 Q27689053-1BFF9C67-9046-45C4-B6CC-1EDEFB6EFE20 Q28079206-C2F8C39E-C2B4-41DB-A1BF-33FE3B6E177C Q28079379-3D4D7B11-26CB-435E-9726-F11DA5464BF0 Q28389296-B2652162-2B2B-4698-B891-449C50A8AC51 Q28394732-00AC963F-98C1-4DE5-8017-72DB54DFEE1D Q28396785-B5EAA3DC-AEFE-42E6-ADB3-0DBA6D5E1D83 Q28397785-B4B439DD-E85F-4D24-AECE-124CCB15B8F7 Q33847548-C1CAD6DA-E86A-4B70-BA99-C7BC4AFC6213 Q34464138-298B9B2F-E800-4622-9EDD-6B98BEBF1F84 Q34557246-FDE2F69C-2D89-4AB3-9C89-78BB90102ED2 Q34590185-F0CE359D-9B8A-4AEF-BF0A-AEDE74AE3B0B Q34667239-F6CBD558-88A0-4694-A3A6-C5E9DED5C485 Q35039225-0EF462F6-BA41-4207-9334-4248D2258BBE Q35044490-F0BF5D1A-C1A3-4ED1-B283-80EC05BFB1AA Q35200121-4C791A37-1203-4670-A627-B5F5E5233EAC Q35641233-AFC7039D-50E8-4427-8725-D6B655167E00 Q36123780-5562C0F6-225C-4322-8008-CE35FAA25FE5 Q36674740-CA6C9AC2-B7AC-4C46-BAE3-CD280B246DB8 Q36732766-29314797-1407-4594-B777-4BD8939E7F1B Q37647941-F284E239-115E-4513-88AC-A5C9613896C4 Q37866170-9F4F26FF-D716-47E7-BA83-521A3BDB2C05 Q38074340-664ABA09-A066-4078-AB15-D18689F48005 Q38206577-C3ED356C-C38B-40BF-AC74-1D62773C1624 Q38481021-B01D541F-D9C6-4765-A454-C22B0EB170BC Q38645013-F5BA0649-746F-4F2E-92A7-635A53399DE8 Q38692790-6020E2F0-6FAC-4567-8C35-2A1F869367A5 Q38950400-9D44DA71-3E3D-4944-99CA-AA06FFFEE55C Q41098388-A73AEAF5-A1B3-4222-81EE-2DE452C2DC64 Q41662736-46E77092-9BCA-4B18-82FB-F84D0891B23B Q41883957-F407B5AA-0B4C-4761-82D6-7EDC12C24D0E Q41895711-878806F7-92EC-4EE9-9AE5-0AFB1F978198 Q42010967-AD054AF9-DE06-4171-9FC8-41124AF7B8E4 Q42499967-A9D83642-8CB5-4F5D-A15B-2E33D7D210A9 Q42653178-7E8BD07F-785C-4969-8419-F255AB14A2E9 Q42704487-CE463513-44CC-4AF0-A41B-D4F79EBA5FF3 Q44360675-53B17AF8-C7CA-4F08-8CB4-1559B028AF63

P2860

Different susceptibility to the Parkinson's toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1

http://www.wikidata.org/entity/Q33646741

description

2010 nî lūn-bûn

@nan

2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Different susceptibility to th ...... s target gene heme oxygenase-1

@ast

Different susceptibility to th ...... s target gene heme oxygenase-1

@en

type

label

Different susceptibility to th ...... s target gene heme oxygenase-1

@ast

Different susceptibility to th ...... s target gene heme oxygenase-1

@en

prefLabel

Different susceptibility to th ...... s target gene heme oxygenase-1

@ast

Different susceptibility to th ...... s target gene heme oxygenase-1

@en

P1433

Q33646741-DF74FC92-0038-494E-AEAA-ECF26335AC3B

P1476

Q33646741-058C1DCF-46CC-4A32-B7F9-C95A8BCB04D4

P2093

Q33646741-0F220AA6-73F2-4E79-A403-2A5E04D1C24B

Q33646741-6988A67D-C5DA-4D43-BCB5-F147E30DC779

Q33646741-916E1F01-CCB8-486A-BB16-C682EBFC7E40

Q33646741-AE88B47B-E36A-4272-9CCB-B6B642902DC7

Q33646741-D70F2C6A-276E-4A2E-956C-E8725DE623FC

Q33646741-FAF799CA-3EF9-4E28-98CC-6818237D76A4

P2860

Q33646741-03ED3271-7B27-4B3B-A90D-33D0D823CEA2

Q33646741-08752C61-1FC7-40F1-AB53-C5D11D01D32C

Q33646741-0F4CA24E-4D73-4D0E-BFC4-7A6EE7F6CBAD

Q33646741-1B34991D-D849-435D-BC64-66DE39C10E4D

Q33646741-1C2B3CC6-D0AE-4589-857F-0366EC51E846

Q33646741-2408C97D-9D9F-45FD-A076-B644E5D74C8D

Q33646741-317C2581-F413-4486-9531-652D1B1D3CB0

Q33646741-32245FD6-6CFF-4070-8C5E-7EFD95438CD2

Q33646741-32B688C5-CDE5-49C5-B926-192B54D68FD1

Q33646741-32EA3A61-FD9E-4A14-B36C-DBD3BAA8D5AC

P304

Q33646741-10C8F04C-5C23-4C6D-9ECD-C799CB41E125

P31

Q33646741-1BE78B96-F4FB-4045-B551-12D0C29E3F89

P356

Q33646741-4357DF20-2124-4A7F-997F-9C558AD3BB72

P407

Q33646741-9E70A47B-A934-4292-AC94-127A7CB2E25B

P433

Q33646741-CBB9588A-C568-4A86-9BB6-91BE7D79CED8

P478

Q33646741-16E6CBB6-9CCF-4A0D-B52F-3BEDBA214E28

P50

Q33646741-14045B0C-236A-4804-9762-30107B641C45

Q33646741-1C492A4C-186B-4F53-8B3F-FAC96FC93935

Q33646741-84BD5853-85A6-4C20-8A0B-04FC72097EE1

Q33646741-F9D65DDA-23A6-44C6-982E-730045013295

P577

Q33646741-6AE91708-F7BA-442D-BF57-931DDFA44B32

P5875

Q33646741-285B9C1F-1406-49CB-B5A6-66778C874C53

P698

Q33646741-D5864B39-3DB0-46BF-A887-B3EDA296A17D

P921

Q33646741-38D3E03D-7485-4A54-BB5C-A049F8B4DBC0

P932

Q33646741-A0538B64-0E9B-4571-8DBB-9D3613FDD71B

P356

JOURNAL.PONE.0011838

P1433

P1476

Different susceptibility to th ...... s target gene heme oxygenase-1

@en

P2093

Agnieszka Jazwa

http://www.w3.org/2001/XMLSchema#string

Ana I Rojo

http://www.w3.org/2001/XMLSchema#string

Anna Stachurska

http://www.w3.org/2001/XMLSchema#string

Javier Fernández-Ruiz

http://www.w3.org/2001/XMLSchema#string

Jozef Dulak

http://www.w3.org/2001/XMLSchema#string

Nadia G Innamorato

http://www.w3.org/2001/XMLSchema#string

P2860

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling

Carbon monoxide, reactive oxygen signaling, and oxidative stress

Aging: a theory based on free radical and radiation chemistry

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

CO-metal interaction: Vital signaling from a lethal gas

Genetic evidence that small maf proteins are essential for the activation of antioxidant response element-dependent genes.

Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress

Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of Parkinson's disease.

P304

e11838

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1371/JOURNAL.PONE.0011838

http://www.w3.org/2001/XMLSchema#string

P407

P433

7

http://www.w3.org/2001/XMLSchema#string

P478

5

http://www.w3.org/2001/XMLSchema#string

P50

Antonio Cuadrado

Alicja Józkowicz

Concepción García

Anna Grochot-Przęczek

P577

2010-07-28T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

45441229

http://www.w3.org/2001/XMLSchema#string

P698

20676377

http://www.w3.org/2001/XMLSchema#string

P921

Parkinson's disease

P932

2911386

http://www.w3.org/2001/XMLSchema#string