Is the role of the small intestine in first-pass metabolism overemphasized?
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Predicting Drug Extraction in the Human Gut Wall: Assessing Contributions from Drug Metabolizing Enzymes and Transporter Proteins using Preclinical ModelsInteractions between CYP3A4 and Dietary PolyphenolsIntestinal and hepatic expression of cytochrome P450s and mdr1a in rats with indomethacin-induced small intestinal ulcersA comparative evaluation of models to predict human intestinal metabolism from nonclinical data.Prediction of hepatic clearance in human from in vitro data for successful drug development.Optimization of intestinal microsomal preparation in the rat: A systematic approach to assess the influence of various methodologies on metabolic activity and scaling factors.Role of intestinal cytochrome P450 (P450) in modulating the bioavailability of oral lovastatin: insights from studies on the intestinal epithelium-specific P450 reductase knockout mouse.Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers.Human pharmacogenomic variations and their implications for antifungal efficacy.Intravenous versus Oral Acetaminophen for Pain: Systematic Review of Current Evidence to Support Clinical Decision-Making.Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolismPredicting the impact of diet and enzymopathies on human small intestinal epithelial cells.Atomoxetine: A Review of Its Pharmacokinetics and Pharmacogenomics Relative to Drug Disposition.The conduct of drug metabolism studies considered good practice (I): analytical systems and in vivo studiesGut Wall Metabolism. Application of Pre-Clinical Models for the Prediction of Human Drug Absorption and First-Pass Elimination.Loss of orally administered drugs in GI tract.Quantitative Prediction of Drug-Drug Interactions Involving Inhibitory Metabolites in Drug Development: How Can Physiologically Based Pharmacokinetic Modeling Help?The Contributions of Human Mini-Intestines to the Study of Intestinal Physiology and Pathophysiology.Regulatory mechanisms to control tissue alpha-tocopherol.Review of antimicrobial use and considerations in the elderly population.
P2860
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P2860
Is the role of the small intestine in first-pass metabolism overemphasized?
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Is the role of the small intestine in first-pass metabolism overemphasized?
@ast
Is the role of the small intestine in first-pass metabolism overemphasized?
@en
type
label
Is the role of the small intestine in first-pass metabolism overemphasized?
@ast
Is the role of the small intestine in first-pass metabolism overemphasized?
@en
prefLabel
Is the role of the small intestine in first-pass metabolism overemphasized?
@ast
Is the role of the small intestine in first-pass metabolism overemphasized?
@en
P2093
P1476
Is the role of the small intestine in first-pass metabolism overemphasized?
@en
P2093
P304
P577
1999-06-01T00:00:00Z