Gut Wall Metabolism. Application of Pre-Clinical Models for the Prediction of Human Drug Absorption and First-Pass Elimination. - Wikidata - awgldk - TriplyDB

Gut Wall Metabolism. Application of Pre-Clinical Models for the Prediction of Human Drug Absorption and First-Pass Elimination.

Gut Wall Metabolism. Application of Pre-Clinical Models for the Prediction of Human Drug Absorption and First-Pass Elimination.

http://www.wikidata.org/entity/Q37600381

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A comparative evaluation of models to predict human intestinal metabolism from nonclinical data.Optimization of intestinal microsomal preparation in the rat: A systematic approach to assess the influence of various methodologies on metabolic activity and scaling factors.Development of a validated UPLC-MS/MS method for determination of humantenmine in rat plasma and its application in pharmacokinetics and bioavailability studies.In Silico Prediction for Intestinal Absorption and Brain Penetration of Chemical Pesticides in Humans.Oral drug absorption in pediatrics: the intestinal wall, its developmental changes and current tools for predictions.Molecular docking-based design and development of a highly selective probe substrate for UDP-glucuronosyltransferase 1A10.Semimechanistic Population Pharmacokinetic Model to Predict the Drug-Drug Interaction Between S-ketamine and Ticlopidine in Healthy Human Volunteers

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P2860

Gut Wall Metabolism. Application of Pre-Clinical Models for the Prediction of Human Drug Absorption and First-Pass Elimination.

http://www.wikidata.org/entity/Q37600381

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 10 March 2016

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

Gut Wall Metabolism. Applicati ...... on and First-Pass Elimination.

@en

Gut Wall Metabolism. Applicati ...... on and First-Pass Elimination.

@nl

type

label

Gut Wall Metabolism. Applicati ...... on and First-Pass Elimination.

@en

Gut Wall Metabolism. Applicati ...... on and First-Pass Elimination.

@nl

prefLabel

Gut Wall Metabolism. Applicati ...... on and First-Pass Elimination.

@en

Gut Wall Metabolism. Applicati ...... on and First-Pass Elimination.

@nl

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S12248-016-9889-Y

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The AAPS Journal

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Gut Wall Metabolism. Applicati ...... on and First-Pass Elimination.

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Anna-Lena Ungell

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Christopher R Jones

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Oliver J D Hatley

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Sheila Annie Peters

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P2860

Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability

Application of in silico, in vitro and preclinical pharmacokinetic data for the effective and efficient prediction of human pharmacokinetics.

Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches.

A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes.

Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.

Prediction of drug clearance by glucuronidation from in vitro data: use of combined cytochrome P450 and UDP-glucuronosyltransferase cofactors in alamethicin-activated human liver microsomes.

Is the role of the small intestine in first-pass metabolism overemphasized?

Prediction of human drug clearance by multiple metabolic pathways: integration of hepatic and intestinal microsomal and cytosolic data.

Prediction of human oral plasma concentration-time profiles using preclinical data: comparative evaluation of prediction approaches in early pharmaceutical discovery.

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s12248-016-9889-y

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589-604

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scholarly article

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10.1208/S12248-016-9889-Y

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3

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Amin Rostami-Hodjegan

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2016-03-10T00:00:00Z

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1018005448

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26964996

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5256607

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