A comprehensive, high-resolution map of a gene's fitness landscape - Wikidata - awgldk - TriplyDB

A comprehensive, high-resolution map of a gene's fitness landscape

A comprehensive, high-resolution map of a gene's fitness landscape

http://www.wikidata.org/entity/Q33654337

about

Rational Protein Engineering Guided by Deep Mutational Scanning Fitness Landscapes of Functional RNAs Environmental changes bridge evolutionary valleys Characterization of all possible single-nucleotide change caused amino acid substitutions in the kinase domain of Bruton tyrosine kinase.Detection and sequence/structure mapping of biophysical constraints to protein variation in saturated mutational libraries and protein sequence alignments with a dedicated server Software for the analysis and visualization of deep mutational scanning data.Molecular Determinants of Mutant Phenotypes, Inferred from Saturation Mutagenesis Data Enzyme Efficiency but Not Thermostability Drives Cefotaxime Resistance Evolution in TEM-1 β-Lactamase.Widespread position-specific conservation of synonymous rare codons within coding sequences.Mistranslation can enhance fitness through purging of deleterious mutations.Single-mutation fitness landscapes for an enzyme on multiple substrates reveal specificity is globally encoded An experimentally informed evolutionary model improves phylogenetic fit to divergent lactamase homologs Biophysics of protein evolution and evolutionary protein biophysics Coevolutionary Landscape Inference and the Context-Dependence of Mutations in Beta-Lactamase TEM-1.Massively parallel single-amino-acid mutagenesis How structural and physicochemical determinants shape sequence constraints in a functional enzyme High-resolution sequence-function mapping of full-length proteins.Systematic Mapping of Protein Mutational Space by Prolonged Drift Reveals the Deleterious Effects of Seemingly Neutral Mutations Quantitative Description of a Protein Fitness Landscape Based on Molecular Features.Modular protein switches derived from antibody mimetic proteins.Mutations to Less-Preferred Synonymous Codons in a Highly Expressed Gene of Escherichia coli: Fitness and Epistatic Interactions Evolutionary History of Cathepsin L (L-like) Family Genes in Vertebrates.The Structure of a Thermophilic Kinase Shapes Fitness upon Random Circular Permutation Plasmid-based one-pot saturation mutagenesis.Mistranslation drives the evolution of robustness in TEM-1 β-lactamase.Experimental Estimation of the Effects of All Amino-Acid Mutations to HIV's Envelope Protein on Viral Replication in Cell Culture Functional Segregation of Overlapping Genes in HIV.Triallelic Population Genomics for Inferring Correlated Fitness Effects of Same Site Nonsynonymous Mutations.Large-Effect Beneficial Synonymous Mutations Mediate Rapid and Parallel Adaptation in a Bacterium.Compensating the Fitness Costs of Synonymous Mutations.Using Evolution to Guide Protein Engineering: The Devil IS in the Details.Local fitness landscape of the green fluorescent protein.Identification of positive selection in genes is greatly improved by using experimentally informed site-specific models.phydms: software for phylogenetic analyses informed by deep mutational scanning.Analysis of Large-Scale Mutagenesis Data To Assess the Impact of Single Amino Acid Substitutions.Rapid and Programmable Protein Mutagenesis Using Plasmid Recombineering.Fluorescence-Based Reporters for Detection of Mutagenesis in E. coli.Quantifying and understanding the fitness effects of protein mutations: Laboratory versus nature Extensively Parameterized Mutation-Selection Models Reliably Capture Site-Specific Selective Constraint.Mutation effects predicted from sequence co-variation.

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A comprehensive, high-resolution map of a gene's fitness landscape

http://www.wikidata.org/entity/Q33654337

description

2014 nî lūn-bûn

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2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի փետրվարին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

A comprehensive, high-resolution map of a gene's fitness landscape

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A comprehensive, high-resolution map of a gene's fitness landscape

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A comprehensive, high-resolution map of a gene's fitness landscape

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Molecular Biology and Evolution

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A comprehensive, high-resolution map of a gene's fitness landscape

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Elad Firnberg

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Jason W Labonte

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Jeffrey J Gray

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P2860

Distribution of fitness effects caused by single-nucleotide substitutions in bacteriophage f1

The distribution of fitness effects caused by single-nucleotide substitutions in an RNA virus

The distribution of fitness effects of new mutations

The genetic theory of adaptation: a brief history

Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis

Amino acid substitution matrices from protein blocks

The genetic code constrains yet facilitates Darwinian evolution

Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs

Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing

A relationship between protein stability and protein function

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1581-1592

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scholarly article

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10.1093/MOLBEV/MSU081

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6

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31

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Marc Ostermeier

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2014-02-23T00:00:00Z

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260379515

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