Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 provides renoprotection in long-term diabetic nephropathy. - Wikidata - awgldk - TriplyDB

Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 provides renoprotection in long-term diabetic nephropathy.

Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 provides renoprotection in long-term diabetic nephropathy.

http://www.wikidata.org/entity/Q33660629

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The Nucleotide Oligomerization Domain-Like Receptors in Kidney Injury Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes Pharmacology and Clinical Drug Candidates in Redox Medicine The balance of powers: Redox regulation of fibrogenic pathways in kidney injury Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement Reactive Oxygen-Related Diseases: Therapeutic Targets and Emerging Clinical Indications Role of NADPH Oxidase in Metabolic Disease-Related Renal Injury: An Update Targeting Mitochondria and Reactive Oxygen Species-Driven Pathogenesis in Diabetic Nephropathy Obesity and Diabetic Kidney Disease: Role of Oxidant Stress and Redox Balance Mitochondrial hormesis and diabetic complications Updates of reactive oxygen species in melanoma etiology and progression.Inhibition of NOX1/4 with GKT137831: a potential novel treatment to attenuate neuroglial cell inflammation in the retina.Combined NOX1/4 inhibition with GKT137831 in mice provides dose-dependent reno- and atheroprotection even in established micro- and macrovascular disease.Nox-4 deletion reduces oxidative stress and injury by PKC-α-associated mechanisms in diabetic nephropathy.Reactive oxygen species as important determinants of medullary flow, sodium excretion, and hypertension Upstream regulators and downstream effectors of NADPH oxidases as novel therapeutic targets for diabetic kidney disease.p47(phox) contributes to albuminuria and kidney fibrosis in mice.Targeting NADPH oxidase with a novel dual Nox1/Nox4 inhibitor attenuates renal pathology in type 1 diabetes.Nox Inhibitors & Therapies: Rational Design of Peptidic and Small Molecule Inhibitors Myocardin-related Transcription Factor Regulates Nox4 Protein Expression: LINKING CYTOSKELETAL ORGANIZATION TO REDOX STATE.Effects of p67phox on the mitochondrial oxidative state in the kidney of Dahl salt-sensitive rats: optical fluorescence 3-D cryoimaging Mechanisms of bradykinin-induced expression of connective tissue growth factor and nephrin in podocytes.Evidence of the Importance of Nox4 in Production of Hypertension in Dahl Salt-Sensitive Rats.Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease Activation of endothelial NAD(P)H oxidase accelerates early glomerular injury in diabetic mice Corosolic acid inhibits the proliferation of glomerular mesangial cells and protects against diabetic renal damage NADPH Oxidase-4 Overexpression Is Associated With Epithelial Ciliary Dysfunction in Neutrophilic Asthma Pathophysiology of gadolinium-associated systemic fibrosis Diabetes and Kidney Disease: Role of Oxidative Stress.mTORC2 Signaling Regulates Nox4-Induced Podocyte Depletion in Diabetes.NADPH oxidase 4 deficiency increases tubular cell death during acute ischemic reperfusion injury.Inhibition of the processing of miR-25 by HIPK2-Phosphorylated-MeCP2 induces NOX4 in early diabetic nephropathy.Advances and strategies in NADPH oxidase inhibitors and activators patents.Novel effective drugs for diabetic kidney disease? or not?Nox and renal disease.APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury.Are reactive oxygen species still the basis for diabetic complications?Dissecting fibrosis: therapeutic insights from the small-molecule toolbox.Glucose Homeostasis and Cardiovascular Alterations in Diabetes.Canonical Transient Receptor Potential 6 Channel: A New Target of Reactive Oxygen Species in Renal Physiology and Pathology.

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P2860

Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 provides renoprotection in long-term diabetic nephropathy.

http://www.wikidata.org/entity/Q33660629

description

2014 nî lūn-bûn

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2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի փետրվարին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Genetic targeting or pharmacol ...... ong-term diabetic nephropathy.

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Genetic targeting or pharmacol ...... ong-term diabetic nephropathy.

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type

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Genetic targeting or pharmacol ...... ong-term diabetic nephropathy.

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Genetic targeting or pharmacol ...... ong-term diabetic nephropathy.

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Genetic targeting or pharmacol ...... ong-term diabetic nephropathy.

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Genetic targeting or pharmacol ...... ong-term diabetic nephropathy.

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Journal of the American Society of Nephrology

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Genetic targeting or pharmacol ...... ong-term diabetic nephropathy.

@en

P2093

Cedric Szyndralewiez

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David Barit

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Freddy Heitz

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Harald H H W Schmidt

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Jay C Jha

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Jun Okabe

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Karin A Jandeleit-Dahm

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Kirstin Wingler

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Mark E Cooper

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Stephen P Gray

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P2860

Identification of renox, an NAD(P)H oxidase in kidney

Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration

Role of NADPH oxidase 4 in lipopolysaccharide-induced proinflammatory responses by human aortic endothelial cells

Subcellular localization of Nox4 and regulation in diabetes

Decreased blood pressure in NOX1-deficient mice

Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18.

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

Dedifferentiation of immortalized human podocytes in response to transforming growth factor-β: a model for diabetic podocytopathy.

NAD(P)H oxidase and uncoupled nitric oxide synthase are major sources of glomerular superoxide in rats with experimental diabetic nephropathy.

NAD(P)H oxidase mediates TGF-beta1-induced activation of kidney myofibroblasts.

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1237-1254

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10.1681/ASN.2013070810

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6

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25

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2014-02-07T00:00:00Z

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24511132

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4033375

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