Targeting NADPH oxidase with a novel dual Nox1/Nox4 inhibitor attenuates renal pathology in type 1 diabetes.
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Pharmacology and Clinical Drug Candidates in Redox MedicineThe Role of Hydrogen Sulfide in Renal SystemRole of NADPH Oxidase in Metabolic Disease-Related Renal Injury: An UpdateStore-operated calcium entry and diabetic complicationsMononuclear-macrophages but not neutrophils act as major infiltrating anti-leptospiral phagocytes during leptospirosis.Combined NOX1/4 inhibition with GKT137831 in mice provides dose-dependent reno- and atheroprotection even in established micro- and macrovascular disease.Regulation of Nox enzymes expression in vascular pathophysiology: Focusing on transcription factors and epigenetic mechanisms.Mechanisms of bradykinin-induced expression of connective tissue growth factor and nephrin in podocytes.Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney DiseaseAsymmetric Dimethylarginine Limits the Efficacy of Simvastatin Activating Endothelial Nitric Oxide Synthase.Drug discovery in focal and segmental glomerulosclerosisPathophysiology of gadolinium-associated systemic fibrosisDiabetes and Kidney Disease: Role of Oxidative Stress.APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury.Tubular atrophy in the pathogenesis of chronic kidney disease progression.Scar management in burn injuries using drug delivery and molecular signaling: Current treatments and future directions.Canonical Transient Receptor Potential 6 Channel: A New Target of Reactive Oxygen Species in Renal Physiology and Pathology.Hydrogen Sulfide in Renal Physiology and Disease.Targeting of NADPH oxidase in vitro and in vivo suppresses fibroblast activation and experimental skin fibrosis.The next generation of therapeutics for chronic kidney diseaseTargeting inflammation in diabetic kidney disease: early clinical trials.Therapeutic potential of NADPH oxidase 1/4 inhibitors.Free radical scavenging decreases endothelin-1 excretion and glomerular albumin permeability during type 1 diabetes.Novel avenues for treating diabetic nephropathy: new investigational drugs.Centrality of bone marrow in the severity of gadolinium-based contrast-induced systemic fibrosis.Serotonin and Its Receptor as a New Antioxidant Therapeutic Target for Diabetic Kidney DiseaseDiabetic Nephropathy: a Tangled Web to Unweave.NADPH Oxidase 4 at the Nexus of Diabetes, Reactive Oxygen Species, and Renal Metabolism.A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: possible role of peroxisomal and mitochondrial biogenesis.FL-926-16, a novel bioavailable carnosinase-resistant carnosine derivative, prevents onset and stops progression of diabetic nephropathy in db/db mice.Hydrogen sulfide inhibits high glucose-induced NADPH oxidase 4 expression and matrix increase by recruiting inducible nitric oxide synthase in kidney proximal tubular epithelial cells.NADPH oxidase-2 mediates zinc deficiency-induced oxidative stress and kidney damage.Mitochondria-targeted peptide SS-31 attenuates renal injury via an antioxidant effect in diabetic nephropathy.Podocyte-specific Nox4 deletion affords renoprotection in a mouse model of diabetic nephropathy.Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice.The role of the Nox4-derived ROS-mediated RhoA/Rho kinase pathway in rat hypertension induced by chronic intermittent hypoxia.K+ deficiency caused defects in renal tubular cell proliferation, oxidative stress response, tissue repair and tight junction integrity, but enhanced energy production, proteasome function and cellular K+ uptake.Inhibition of Nox4-dependent ROS signaling attenuates prostate fibroblast activation and abrogates stromal-mediated pro-tumorigenic interactions.Nox4 is a Target for Tuberin Deficiency Syndrome.Glomerular Endothelial Cells Stress and Cross-Talk With Podocytes in the Development of Diabetic Kidney Disease.
P2860
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P2860
Targeting NADPH oxidase with a novel dual Nox1/Nox4 inhibitor attenuates renal pathology in type 1 diabetes.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Targeting NADPH oxidase with a ...... pathology in type 1 diabetes.
@ast
Targeting NADPH oxidase with a ...... pathology in type 1 diabetes.
@en
type
label
Targeting NADPH oxidase with a ...... pathology in type 1 diabetes.
@ast
Targeting NADPH oxidase with a ...... pathology in type 1 diabetes.
@en
prefLabel
Targeting NADPH oxidase with a ...... pathology in type 1 diabetes.
@ast
Targeting NADPH oxidase with a ...... pathology in type 1 diabetes.
@en
P2093
P2860
P1476
Targeting NADPH oxidase with a ...... pathology in type 1 diabetes.
@en
P2093
Cédric Szyndralewiez
Doug-Yoon Lee
Francesca Bruno
Hanna E Abboud
Jeffrey L Barnes
Karen Block
Khaled Khazim
Paolo Fanti
Rita C Cavaglieri
Sachin Thakur
P2860
P304
P356
10.1152/AJPRENAL.00396.2014
P577
2015-02-04T00:00:00Z