RagA, but not RagB, is essential for embryonic development and adult mice. - Wikidata - awgldk - TriplyDB

RagA, but not RagB, is essential for embryonic development and adult mice.

RagA, but not RagB, is essential for embryonic development and adult mice.

http://www.wikidata.org/entity/Q33671851

about

Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot Beyond indigestion: emerging roles for lysosome-based signaling in human disease mTOR signaling in tumorigenesis C9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling.The Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond.Rag GTPases are cardioprotective by regulating lysosomal function.Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade.Mutations of RagA GTPase in mTORC1 Pathway Are Associated with Autosomal Dominant Cataracts.Multiple amino acid sensing inputs to mTORC1.Sestrin regulation of TORC1: Is Sestrin a leucine sensor?Amino acid-insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells.Regulation of autophagy by amino acids and MTOR-dependent signal transduction.mTOR: a pharmacologic target for autophagy regulation.Rag GTPase in amino acid signaling.Regulation of metabolic health and aging by nutrient-sensitive signaling pathways.Nutrient sensing and TOR signaling in yeast and mammals.Sestrin2 inhibits mTORC1 through modulation of GATOR complexes.Interleukin 6 protects pancreatic β cells from apoptosis by stimulation of autophagy.The Rag-Ragulator Complex Regulates Lysosome Function and Phagocytic Flux in Microglia.mTORC1 as the main gateway to autophagy.Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase.mTORC1 and Nutrient Homeostasis: The Central Role of the Lysosome.

P2860

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P2860

RagA, but not RagB, is essential for embryonic development and adult mice.

http://www.wikidata.org/entity/Q33671851

description

2014 nî lūn-bûn

@nan

2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

RagA, but not RagB, is essential for embryonic development and adult mice.

@ast

RagA, but not RagB, is essential for embryonic development and adult mice.

@en

type

label

RagA, but not RagB, is essential for embryonic development and adult mice.

@ast

RagA, but not RagB, is essential for embryonic development and adult mice.

@en

prefLabel

RagA, but not RagB, is essential for embryonic development and adult mice.

@ast

RagA, but not RagB, is essential for embryonic development and adult mice.

@en

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P356

J.DEVCEL.2014.03.017

P1433

Developmental Cell

P1476

RagA, but not RagB, is essential for embryonic development and adult mice.

@en

P2093

Alejo Efeyan

http://www.w3.org/2001/XMLSchema#string

Angelina M Bilate

http://www.w3.org/2001/XMLSchema#string

David M Sabatini

http://www.w3.org/2001/XMLSchema#string

Dudley W Lamming

http://www.w3.org/2001/XMLSchema#string

Lawrence D Schweitzer

http://www.w3.org/2001/XMLSchema#string

Oktay Kirak

http://www.w3.org/2001/XMLSchema#string

Steven Chang

http://www.w3.org/2001/XMLSchema#string

P2860

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development

mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

mTOR signaling in growth control and disease

p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis

Autophagy fights disease through cellular self-digestion

Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

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321-329

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scholarly article

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10.1016/J.DEVCEL.2014.03.017

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3

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29

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261918046

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24768164

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