TDP-43 is a developmentally regulated protein essential for early embryonic development.
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TARDBP mutation analysis in TDP-43 proteinopathies and deciphering the toxicity of mutant TDP-43Conjoint pathologic cascades mediated by ALS/FTLD-U linked RNA-binding proteins TDP-43 and FUSPrion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative diseaseTDP-43: a new player on the AD field?Pathological mechanisms underlying TDP-43 driven neurodegeneration in FTLD-ALS spectrum disordersMouse models of frontotemporal dementiaConverging mechanisms in ALS and FTD: disrupted RNA and protein homeostasisPotential mechanisms of progranulin-deficient FTLDThe function of RNA-binding proteins at the synapse: implications for neurodegenerationTherapeutic and diagnostic challenges for frontotemporal dementiaDoes a loss of TDP-43 function cause neurodegeneration?TDP-43 aggregation in neurodegeneration: are stress granules the key?The neurogenetics of alternative splicingTDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets.Akirin2 is essential for the formation of the cerebral cortexIdentification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexesTDP-43 is a transcriptional repressor: the testis-specific mouse acrv1 gene is a TDP-43 target in vivo.Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis.Expansive gene transfer in the rat CNS rapidly produces amyotrophic lateral sclerosis relevant sequelae when TDP-43 is overexpressed.ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43.Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth.Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis.Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in ratsWild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS.Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.Development of a novel nonradiometric assay for nucleic acid binding to TDP-43 suitable for high-throughput screening using AlphaScreen technology.TDP-43 regulates its mRNA levels through a negative feedback loop.The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanismDrosophila lines with mutant and wild type human TDP-43 replacing the endogenous gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects.Neuronal function and dysfunction of Drosophila dTDPInteraction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43.Neurodegenerative models in Drosophila: polyglutamine disorders, Parkinson disease, and amyotrophic lateral sclerosis.Nuclear TAR DNA-binding protein 43: A new target for amyotrophic lateral sclerosis treatmentAltered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice.Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism.TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor.Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA.Ascl1 controls the number and distribution of astrocytes and oligodendrocytes in the gray matter and white matter of the spinal cord.Alteration of POLDIP3 splicing associated with loss of function of TDP-43 in tissues affected with ALS
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P2860
TDP-43 is a developmentally regulated protein essential for early embryonic development.
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
TDP-43 is a developmentally regulated protein essential for early embryonic development.
@ast
TDP-43 is a developmentally regulated protein essential for early embryonic development.
@en
type
label
TDP-43 is a developmentally regulated protein essential for early embryonic development.
@ast
TDP-43 is a developmentally regulated protein essential for early embryonic development.
@en
prefLabel
TDP-43 is a developmentally regulated protein essential for early embryonic development.
@ast
TDP-43 is a developmentally regulated protein essential for early embryonic development.
@en
P2093
P2860
P356
P1476
TDP-43 is a developmentally regulated protein essential for early embryonic development.
@en
P2093
Chantelle F Sephton
Colleen M Dewey
Joachim Herz
Paul Mayer
Shannon K Good
Stan Atkin
P2860
P304
P356
10.1074/JBC.M109.061846
P407
P577
2009-12-29T00:00:00Z