Comparative effects of pH and ionic strength on protein-protein interactions, unfolding, and aggregation for IgG1 antibodies.
about
Development and comparative study of chemosynthesized antigen and mimotope-based immunoassays for class-specific analysis of O,O-dimethyl organophosphorus pesticidesModulating non-native aggregation and electrostatic protein-protein interactions with computationally designed single-point mutationsInvestigating monoclonal antibody aggregation using a combination of H/DX-MS and other biophysical measurementsInvestigating Therapeutic Protein Structure with Diethylpyrocarbonate Labeling and Mass Spectrometry.Aggregation mechanism of an IgG2 and two IgG1 monoclonal antibodies at low pH: from oligomers to larger aggregates.Multimodal chromatography: an efficient tool in downstream processing of proteins.Conformational stability as a design target to control protein aggregation.High-throughput analysis of concentration-dependent antibody self-association.Aggregates of α-chymotrypsinogen anneal to access more stable statesTherapeutic protein aggregation: mechanisms, design, and control.Osmotic virial coefficients for model protein and colloidal solutions: importance of ensemble constraints in the analysis of light scattering data.Role of anisotropic interactions for proteins and patchy nanoparticles.Structure based descriptors for the estimation of colloidal interactions and protein aggregation propensitiesDetermination of the second virial coefficient of bovine serum albumin under varying pH and ionic strength by composition-gradient multi-angle static light scattering.Reexamining protein-protein and protein-solvent interactions from Kirkwood-Buff analysis of light scattering in multi-component solutions.Weak protein interactions and pH- and temperature-dependent aggregation of human Fc1.Identifying protein aggregation mechanisms and quantifying aggregation rates from combined monomer depletion and continuous scatteringHigh-throughput biophysical analysis of protein therapeutics to examine interrelationships between aggregate formation and conformational stability.A multiscale view of therapeutic protein aggregation: a colloid science perspective.High-throughput screening for developability during early-stage antibody discovery using self-interaction nanoparticle spectroscopy.Influence of Label and Charge Density on the Association of the Therapeutic Monoclonal Antibodies Trastuzumab and Cetuximab Conjugated to Anionic Fluorophores.Self-assembling peptide and protein amyloids: from structure to tailored function in nanotechnology.Intrinsic fluorescence-based at situ soft sensor for monitoring monoclonal antibody aggregation.Physical characterization and in vitro biological impact of highly aggregated antibodies separated into size-enriched populations by fluorescence-activated cell sorting.From osmotic second virial coefficient (B22 ) to phase behavior of a monoclonal antibody.Engineering an improved IgG4 molecule with reduced disulfide bond heterogeneity and increased Fab domain thermal stability.Hydrogen exchange mass spectrometry reveals protein interfaces and distant dynamic coupling effects during the reversible self-association of an IgG1 monoclonal antibody.Octupolar approximation for the excluded volume of axially symmetric convex bodies.Scale-down models to optimize a filter train for the downstream purification of recombinant pharmaceutical proteins produced in tobacco leaves.Both protein adsorption and aggregation contribute to shear yielding and viscosity increase in protein solutions.Insights into the potential aggregation liabilities of the b12 Fab fragment via elevated temperature molecular dynamics.Challenges and Opportunities for the Subcutaneous Delivery of Therapeutic Proteins.Biophysical characterization and molecular simulation of electrostatically driven self-association of a single-chain antibody.Emerging methods for identifying monoclonal antibodies with low propensity to self-associate during the early discovery process.
P2860
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P2860
Comparative effects of pH and ionic strength on protein-protein interactions, unfolding, and aggregation for IgG1 antibodies.
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Comparative effects of pH and ...... gregation for IgG1 antibodies.
@ast
Comparative effects of pH and ...... gregation for IgG1 antibodies.
@en
type
label
Comparative effects of pH and ...... gregation for IgG1 antibodies.
@ast
Comparative effects of pH and ...... gregation for IgG1 antibodies.
@en
prefLabel
Comparative effects of pH and ...... gregation for IgG1 antibodies.
@ast
Comparative effects of pH and ...... gregation for IgG1 antibodies.
@en
P2093
P356
P1476
Comparative effects of pH and ...... gregation for IgG1 antibodies.
@en
P2093
Adeola O Grillo
Christopher J Roberts
Erinc Sahin
Melissa D Perkins
P304
P356
10.1002/JPS.22198
P407
P577
2010-12-01T00:00:00Z