Engineering an improved IgG4 molecule with reduced disulfide bond heterogeneity and increased Fab domain thermal stability.

Engineering an improved IgG4 molecule with reduced disulfide bond heterogeneity and increased Fab domain thermal stability.

Item
http://www.wikidata.org/entity/Q42234345
Stability engineering of the human antibody repertoireExperimental and in silico modelling analyses of the gene expression pathway for recombinant antibody and by-product production in NS0 cell linesEffects of localized interactions and surface properties on stability of protein-based therapeutics.The S228P mutation prevents in vivo and in vitro IgG4 Fab-arm exchange as demonstrated using a combination of novel quantitative immunoassays and physiological matrix preparation.Site-targeted mutagenesis for stabilization of recombinant monoclonal antibody expressed in tobacco (Nicotiana tabacum) plants.Post-translational structural modifications of immunoglobulin G and their effect on biological activity.Relative stabilities of IgG1 and IgG4 Fab domains: influence of the light-heavy interchain disulfide bond architectureIgG light chain-independent secretion of heavy chain dimers: consequence for therapeutic antibody production and design.Monovalent IgG4 molecules: immunoglobulin Fc mutations that result in a monomeric structure.Non-antigen-contacting region of an asymmetric bispecific antibody to factors IXa/X significantly affects factor VIII-mimetic activity.Molecular Insights into the Thermal Stability of mAbs with Variable-Temperature Ion-Mobility Mass Spectrometry.Engineered hexavalent Fc proteins with enhanced Fc-gamma receptor avidity provide insights into immune-complex interactions
P2860

Engineering an improved IgG4 molecule with reduced disulfide bond heterogeneity and increased Fab domain thermal stability.

Item
http://www.wikidata.org/entity/Q42234345
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Engineering an improved IgG4 m ...... Fab domain thermal stability.
@en
Engineering an improved IgG4 m ...... Fab domain thermal stability.
@nl
type
label
Engineering an improved IgG4 m ...... Fab domain thermal stability.
@en
Engineering an improved IgG4 m ...... Fab domain thermal stability.
@nl
prefLabel
Engineering an improved IgG4 m ...... Fab domain thermal stability.
@en
Engineering an improved IgG4 m ...... Fab domain thermal stability.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P932
P356
P1433
P1476
Engineering an improved IgG4 m ...... d Fab domain thermal stability
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P932