Autocrine transformation by chimeric signal peptide-basic fibroblast growth factor: reversal by suramin.
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An acidic fibroblast growth factor protein generated by alternate splicing acts like an antagonistLeads for development of new naphthalenesulfonate derivatives with enhanced antiangiogenic activity: crystal structure of acidic fibroblast growth factor in complex with 5-amino-2-naphthalene sulfonateSuramin rapidly alters cellular tyrosine phosphorylation in prostate cancer cell lines.Development of a high throughput screening assay for inhibitors of fibroblast growth factor-receptor-heparin interactions.Suramin inhibits bFGF-induced endothelial cell proliferation and angiogenesis in the chick chorioallantoic membrane.Interference with endogenous ras function inhibits cellular responses to wounding.Sequestration and release of basic fibroblast growth factor.Isolation of peptides that inhibit binding of basic fibroblast growth factor to its receptor from a random phage-epitope libraryCloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cellsModulation of fibroblast growth factor-2 receptor binding, dimerization, signaling, and angiogenic activity by a synthetic heparin-mimicking polyanionic compound.Fibroblast growth factor receptors participate in the control of mitogen-activated protein kinase activity during nerve growth factor-induced neuronal differentiation of PC12 cells.The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agentsAutocrine growth factor regulation of lysyl oxidase expression in transformed fibroblasts.The comparative release of FGF1 by hypoxia and temperature stress.Expression of the high molecular weight fibroblast growth factor-2 isoform of 210 amino acids is associated with modulation of protein kinases C delta and epsilon and ERK activation.Retention of fibroblast growth factor 3 in the Golgi complex may regulate its export from cells.Extracellular ATP stimulates three different receptor-signal transduction systems in FRTL-5 thyroid cells. Activation of phospholipase C, and inhibition and activation of adenylate cyclase.Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin.Cell transformation by kFGF requires secretion but not glycosylation.Inhibition of cell growth and tumorigenesis of human glioblastoma cells by a neutralizing antibody against human basic fibroblast growth factor.Inhibitory role of the somatostatin receptor SST2 on the intracrine-regulated cell proliferation induced by the 210-amino acid fibroblast growth factor-2 isoform: implication of JAK2.Heparin-binding EGF-like growth factor stimulation of smooth muscle cell migration: dependence on interactions with cell surface heparan sulfatePhosphorothioate oligodeoxynucleotides bind to basic fibroblast growth factor, inhibit its binding to cell surface receptors, and remove it from low affinity binding sites on extracellular matrix.Gene transfer mediated by native versus fibroblast growth factor-retargeted adenoviral vectors into lung cancer cells.Regulation of synovial cell growth. Coexpression of transforming growth factor beta and basic fibroblast growth factor by cultured synovial cells.Differences between phosphotyrosine accumulation and Neu/ErbB-2 receptor expression in astrocytic proliferative processes. Implications for glial oncogenesis.Dual roles of endothelial FGF-2-FGFR1-PDGF-BB and perivascular FGF-2-FGFR2-PDGFRβ signaling pathways in tumor vascular remodeling.Antisense inhibition of basic fibroblast growth factor induces apoptosis in vascular smooth muscle cells.Regulation of proliferation-survival decisions is controlled by FGF1 secretion in retinal pigmented epithelial cells.
P2860
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P2860
Autocrine transformation by chimeric signal peptide-basic fibroblast growth factor: reversal by suramin.
description
1990 nî lūn-bûn
@nan
1990 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
name
Autocrine transformation by ch ...... h factor: reversal by suramin.
@ast
Autocrine transformation by ch ...... h factor: reversal by suramin.
@en
type
label
Autocrine transformation by ch ...... h factor: reversal by suramin.
@ast
Autocrine transformation by ch ...... h factor: reversal by suramin.
@en
prefLabel
Autocrine transformation by ch ...... h factor: reversal by suramin.
@ast
Autocrine transformation by ch ...... h factor: reversal by suramin.
@en
P2860
P356
P1476
Autocrine transformation by ch ...... h factor: reversal by suramin.
@en
P2093
P2860
P304
P356
10.1073/PNAS.87.14.5346
P407
P577
1990-07-01T00:00:00Z