17-Allylamino-17-demethoxygeldanamycin induces downregulation of critical Hsp90 protein clients and results in cell cycle arrest and apoptosis of human urinary bladder cancer cells
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Targeting Hsp90 in urothelial carcinomaHeat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/lpr mouse model of systemic lupus erythematosusA selenosemicarbazone complex with copper efficiently down-regulates the 90-kDa heat shock protein HSP90AA1 and its client proteins in cancer cells.17-AAG suppresses growth and invasion of lung adenocarcinoma cells via regulation of the LATS1/YAP pathway.Targeted inhibition of heat shock protein 90 disrupts multiple oncogenic signaling pathways, thus inducing cell cycle arrest and programmed cell death in human urinary bladder cancer cell linesCan RNAi-mediated hsp90α knockdown in combination with 17-AAG be a therapy for glioma?A novel therapeutic strategy for the treatment of glioma, combining chemical and molecular targeting of hsp90a.The role of heat shock proteins in bladder cancer.Effects of 17-allylamino-17-demethoxygeldanamycin on the induction of apoptosis and cell cycle arrest in HCT-116 cells.Effects of 17-AAG on the cell cycle and apoptosis of H446 cells and the associated mechanisms.17-DMAG induces heat shock protein 90 functional impairment in human bladder cancer cells: knocking down the hallmark traits of malignancy.Dual targeting of heat shock proteins 90 and 70 promotes cell death and enhances the anticancer effect of chemotherapeutic agents in bladder cancerLimited efficacy of specific HDAC6 inhibition in urothelial cancer cells.HSP90 inhibition by 17-DMAG reduces inflammation in J774 macrophages through suppression of Akt and nuclear factor-κB pathways.Potential role of Hsp90 inhibitors in overcoming cisplatin resistance of bladder cancer-initiating cells.Inhibition of aldose reductase prevents angiogenesis in vitro and in vivo.Overexpression of DJ-1 and HSP90α, and loss of PTEN associated with invasive urothelial carcinoma of urinary bladder: Possible prognostic markers.In vitro investigation of the effect of matrix molecules on the behavior of colon cancer cells under the effect of geldanamycin derivative.Pharmacological targeting of HSP90 with 17-AAG induces apoptosis of myogenic cells through activation of the intrinsic pathway.Imaging-guided photo-therapeutic nanoporphyrin synergized HSP90 inhibitor in patient-derived xenograft bladder cancer model.Stromal factors involved in human prostate cancer development, progression and castration resistance.
P2860
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P2860
17-Allylamino-17-demethoxygeldanamycin induces downregulation of critical Hsp90 protein clients and results in cell cycle arrest and apoptosis of human urinary bladder cancer cells
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
17-Allylamino-17-demethoxygeld ...... n urinary bladder cancer cells
@ast
17-Allylamino-17-demethoxygeld ...... n urinary bladder cancer cells
@en
type
label
17-Allylamino-17-demethoxygeld ...... n urinary bladder cancer cells
@ast
17-Allylamino-17-demethoxygeld ...... n urinary bladder cancer cells
@en
prefLabel
17-Allylamino-17-demethoxygeld ...... n urinary bladder cancer cells
@ast
17-Allylamino-17-demethoxygeld ...... n urinary bladder cancer cells
@en
P2093
P2860
P356
P1433
P1476
17-Allylamino-17-demethoxygeld ...... n urinary bladder cancer cells
@en
P2093
Dimitrios J Stravopodis
Gerassimos E Voutsinas
Panagiotis K Karkoulis
P2860
P2888
P356
10.1186/1471-2407-10-481
P407
P577
2010-09-09T00:00:00Z
P5875
P6179
1039046519