Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation. - Wikidata - awgldk - TriplyDB

Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation.

Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation.

http://www.wikidata.org/entity/Q33695751

about

Guidelines for the use and interpretation of assays for monitoring autophagy Growth arrest-specific 1 binds to and controls the maturation and processing of the amyloid-beta precursor protein Dual roles for autophagy: degradation and secretion of Alzheimer's disease Aβ peptide Autophagy and neurodegeneration Cilostazol Modulates Autophagic Degradation of β-Amyloid Peptide via SIRT1-Coupled LKB1/AMPKα Signaling in Neuronal Cells Regulation of ion channels and transporters by AMP-activated kinase (AMPK).Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy.AMPK activation--protean potential for boosting healthspan.A requirement for fatty acid oxidation in the hormone-induced meiotic maturation of mouse oocytes.Small-molecule activators of AMP-activated protein kinase (AMPK), RSVA314 and RSVA405, inhibit adipogenesis.Ginsenoside compound K promotes β-amyloid peptide clearance in primary astrocytes via autophagy enhancement.CALHM1 controls the Ca²⁺-dependent MEK, ERK, RSK and MSK signaling cascade in neurons Novel resveratrol analogues attenuate renal ischemic injury in rats.Macronutrient composition of the diet affects the feeding-mediated down regulation of autophagy in muscle of rainbow trout (O. mykiss).Small molecule adenosine 5'-monophosphate activated protein kinase (AMPK) modulators and human diseases Resveratrol mitigates lipopolysaccharide- and Aβ-mediated microglial inflammation by inhibiting the TLR4/NF-κB/STAT signaling cascade Preconditioning induces sustained neuroprotection by downregulation of adenosine 5'-monophosphate-activated protein kinase.Bioenergy sensing in the brain: the role of AMP-activated protein kinase in neuronal metabolism, development and neurological diseases Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's Disease Inflammaging: disturbed interplay between autophagy and inflammasomes.Targeting AMPK: From Ancient Drugs to New Small-Molecule Activators.Identification of potent small-molecule inhibitors of STAT3 with anti-inflammatory properties in RAW 264.7 macrophages.AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease.Mitochondrial biogenesis: a therapeutic target for neurodevelopmental disorders and neurodegenerative diseases Pharmacologic preconditioning with berberine attenuating ischemia-induced apoptosis and promoting autophagy in neuron AMPK Signaling in the Dorsal Hippocampus Negatively Regulates Contextual Fear Memory Formation.Rapamycin, Autophagy, and Alzheimer's Disease Resveratrol-activated AMPK/SIRT1/autophagy in cellular models of Parkinson's disease.A current pharmacologic agent versus the promise of next generation therapeutics to ameliorate protein misfolding and/or aggregation diseases.The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylation Curcumin-induced upregulation of the anti-tau cochaperone BAG2 in primary rat cortical neurons Regulation of amyloid precursor protein processing by its KFERQ motif.Targeting the LKB1 tumor suppressor.AMP-activated protein kinase: a potential player in Alzheimer's disease.Mammalian target of rapamycin: a valid therapeutic target through the autophagy pathway for Alzheimer's disease?Roles of AMP-activated protein kinase in Alzheimer's disease.Energy dysfunction in Huntington's disease: insights from PGC-1α, AMPK, and CKB.Novel pharmacological modulators of autophagy and therapeutic prospects.Modulating macroautophagy: a neuronal perspective.Autophagy and inflammatory diseases.

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P2860

Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation.

http://www.wikidata.org/entity/Q33695751

description

2010 nî lūn-bûn

@nan

2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Novel synthetic small-molecule ...... amyloid-β peptide degradation.

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Novel synthetic small-molecule ...... amyloid-β peptide degradation.

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Novel synthetic small-molecule ...... amyloid-β peptide degradation.

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Novel synthetic small-molecule ...... amyloid-β peptide degradation.

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Novel synthetic small-molecule ...... amyloid-β peptide degradation

@en

P2093

Cristina d'Abramo

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Haitian Zhao

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Pallavi Chandakkar

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P2860

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

Role of AMP-activated protein kinase in mechanism of metformin action

Alzheimer's Disease

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

AMPK phosphorylation of raptor mediates a metabolic checkpoint

The regulation of AMP-activated protein kinase by phosphorylation

AMPK in the brain: its roles in energy balance and neuroprotection

Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments.

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

TOR signaling in growth and metabolism

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10.1096/FJ.10-167361

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1

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Philippe Marambaud

Valérie Vingtdeux

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