Role of Hsp70 ATPase domain intrinsic dynamics and sequence evolution in enabling its functional interactions with NEFs.
about
Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive reviewMolecular mechanism of allosteric communication in Hsp70 revealed by molecular dynamics simulationsCrystal Structure of DnaK Protein Complexed with Nucleotide Exchange Factor GrpE in DnaK Chaperone System: INSIGHT INTO INTERMOLECULAR COMMUNICATIONStructure and function of Hip, an attenuator of the Hsp70 chaperone cycleCollective dynamics differentiates functional divergence in protein evolutionIdentification of key hinge residues important for nucleotide-dependent allostery in E. coli Hsp70/DnaKBinding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitroEmerging Computational Methods for the Rational Discovery of Allosteric Drugs.Conformational dynamics of nonsynonymous variants at protein interfaces reveals disease association.Structural dynamics flexibility informs function and evolution at a proteome scale.Evol and ProDy for bridging protein sequence evolution and structural dynamicsAllosteric signal transmission in the nucleotide-binding domain of 70-kDa heat shock protein (Hsp70) molecular chaperonesDecipher the mechanisms of protein conformational changes induced by nucleotide binding through free-energy landscape analysis: ATP binding to Hsp70.A career pathway in protein folding: from model peptides to postreductionist protein scienceATPase subdomain IA is a mediator of interdomain allostery in Hsp70 molecular chaperones.Comparative study of the effectiveness and limitations of current methods for detecting sequence coevolutionDancing through Life: Molecular Dynamics Simulations and Network-Centric Modeling of Allosteric Mechanisms in Hsp70 and Hsp110 Chaperone Proteins.Sequence evolution correlates with structural dynamicsComputational Analysis of Residue Interaction Networks and Coevolutionary Relationships in the Hsp70 Chaperones: A Community-Hopping Model of Allosteric Regulation and CommunicationDynamical Structures of Hsp70 and Hsp70-Hsp40 Complexes.Inducing apoptosis of cancer cells using small-molecule plant compounds that bind to GRP78.The Role of Conformational Dynamics and Allostery in the Disease Development of Human Ferritin.Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of TauopathyStructure-based, biophysical annotation of molecular coevolution of acetylcholinesterase.Disrupted hydrogen bond network and impaired ATPase activity in an Hsc70 cysteine mutant.In silico mutational studies of Hsp70 disclose sites with distinct functional attributes.Identification of key residues for protein conformational transition using elastic network model.
P2860
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P2860
Role of Hsp70 ATPase domain intrinsic dynamics and sequence evolution in enabling its functional interactions with NEFs.
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Role of Hsp70 ATPase domain in ...... tional interactions with NEFs.
@ast
Role of Hsp70 ATPase domain in ...... tional interactions with NEFs.
@en
type
label
Role of Hsp70 ATPase domain in ...... tional interactions with NEFs.
@ast
Role of Hsp70 ATPase domain in ...... tional interactions with NEFs.
@en
prefLabel
Role of Hsp70 ATPase domain in ...... tional interactions with NEFs.
@ast
Role of Hsp70 ATPase domain in ...... tional interactions with NEFs.
@en
P2860
P1476
Role of Hsp70 ATPase domain in ...... tional interactions with NEFs.
@en
P2093
Lila M Gierasch
P2860
P356
10.1371/JOURNAL.PCBI.1000931
P50
P577
2010-09-16T00:00:00Z