Phospho-eIF2α level is important for determining abilities of BACE1 reduction to rescue cholinergic neurodegeneration and memory defects in 5XFAD mice
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Spines, plasticity, and cognition in Alzheimer's model miceMechanisms underlying insulin deficiency-induced acceleration of β-amyloidosis in a mouse model of Alzheimer's diseaseLimited effects of an eIF2αS51A allele on neurological impairments in the 5xFAD mouse model of Alzheimer's disease.Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease.Role of Endoplasmic Reticulum Stress in Learning and Memory Impairment and Alzheimer's Disease-Like Neuropathology in the PS19 and APPSwe Mouse Models of Tauopathy and Amyloidosis.PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease.Abnormal vibrissa-related behavior and loss of barrel field inhibitory neurons in 5xFAD transgenics.Sex- and brain region-specific acceleration of β-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's disease.A peptide binding to the β-site of APP improves spatial memory and attenuates Aβ burden in Alzheimer's disease transgenic miceTemporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer's disease.Mechanisms of Alzheimer's Disease Pathogenesis and Prevention: The Brain, Neural Pathology, N-methyl-D-aspartate Receptors, Tau Protein and Other Risk Factors.Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP levelDeletion of the eIF2α Kinase GCN2 fails to rescue the memory decline associated with Alzheimer's disease.Activation of the nuclear receptor PPARδ is neuroprotective in a transgenic mouse model of Alzheimer's disease through inhibition of inflammationIn vivo olfactory model of APP-induced neurodegeneration reveals a reversible cell-autonomous function.A combination Alzheimer's therapy targeting BACE1 and neprilysin in 5XFAD transgenic mice.Beneficial effects of the β-secretase inhibitor GRL-8234 in 5XFAD Alzheimer's transgenic mice lessen during disease progression.Mitochondrial dysfunction and accumulation of the β-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic mice7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease.Fructus mume extracts alleviate cognitive impairments in 5XFAD transgenic miceEffects of BACE1 haploinsufficiency on APP processing and Aβ concentrations in male and female 5XFAD Alzheimer mice at different disease stagesAmyloid β-protein oligomers upregulate the β-secretase, BACE1, through a post-translational mechanism involving its altered subcellular distribution in neuronsAn update of animal models of Alzheimer disease with a reevaluation of plaque depositions.Mechanisms that lessen benefits of β-secretase reduction in a mouse model of Alzheimer's disease.Icariside II Effectively Reduces Spatial Learning and Memory Impairments in Alzheimer's Disease Model Mice Targeting Beta-Amyloid Production.Roles of eIF2α kinases in the pathogenesis of Alzheimer's disease.Forebrain depletion of Rheb GTPase elicits spatial memory deficits in mice.Activation of mTOR: a culprit of Alzheimer's disease?Rheb Inhibits Protein Synthesis by Activating the PERK-eIF2α Signaling CascadeBrain metabolic stress and neuroinflammation at the basis of cognitive impairment in Alzheimer's diseaseEFAD transgenic mice as a human APOE relevant preclinical model of Alzheimer's disease.Translational control by eIF2α in neurons: Beyond the stress response.Does any drug to treat cancer target mTOR and iron hemostasis in neurodegenerative disorders?Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects.
P2860
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P2860
Phospho-eIF2α level is important for determining abilities of BACE1 reduction to rescue cholinergic neurodegeneration and memory defects in 5XFAD mice
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Phospho-eIF2α level is importa ...... d memory defects in 5XFAD mice
@ast
Phospho-eIF2α level is importa ...... d memory defects in 5XFAD mice
@en
type
label
Phospho-eIF2α level is importa ...... d memory defects in 5XFAD mice
@ast
Phospho-eIF2α level is importa ...... d memory defects in 5XFAD mice
@en
prefLabel
Phospho-eIF2α level is importa ...... d memory defects in 5XFAD mice
@ast
Phospho-eIF2α level is importa ...... d memory defects in 5XFAD mice
@en
P2860
P1433
P1476
Phospho-eIF2α level is importa ...... d memory defects in 5XFAD mice
@en
P2093
Latha Devi
Masuo Ohno
P2860
P304
P356
10.1371/JOURNAL.PONE.0012974
P407
P577
2010-09-23T00:00:00Z