Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease.

Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease.

Item
http://www.wikidata.org/entity/Q33844923
Alzheimer-related decrease in CYFIP2 links amyloid production to tau hyperphosphorylation and memory loss.Limited effects of an eIF2αS51A allele on neurological impairments in the 5xFAD mouse model of Alzheimer's disease.Beneficial effects of the β-secretase inhibitor GRL-8234 in 5XFAD Alzheimer's transgenic mice lessen during disease progression.Effects of BACE1 haploinsufficiency on APP processing and Aβ concentrations in male and female 5XFAD Alzheimer mice at different disease stagesAmyloid β-protein oligomers upregulate the β-secretase, BACE1, through a post-translational mechanism involving its altered subcellular distribution in neuronsActivation of GCN2 kinase by ribosome stalling links translation elongation with translation initiation.Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer's disease.BACE1 inhibitor drugs in clinical trials for Alzheimer's disease.Sevoflurane-Induced Endoplasmic Reticulum Stress Contributes to Neuroapoptosis and BACE-1 Expression in the Developing Brain: The Role of eIF2α.Neuroinflammation and Aβ accumulation linked to systemic inflammation are decreased by genetic PKR down-regulation.BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice.Beta-secretase inhibitors in phase I and phase II clinical trials for Alzheimer's disease.Translational attenuation and retinal degeneration in mice with an active integrated stress response.
P2860

Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease.

Item
http://www.wikidata.org/entity/Q33844923
description
2014 nî lūn-bûn
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2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հուլիսին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
@zh-mo
2014年論文
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2014年论文
@wuu
name
Genetic inhibition of phosphor ...... model of Alzheimer's disease.
@ast
Genetic inhibition of phosphor ...... model of Alzheimer's disease.
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type
label
Genetic inhibition of phosphor ...... model of Alzheimer's disease.
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Genetic inhibition of phosphor ...... model of Alzheimer's disease.
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prefLabel
Genetic inhibition of phosphor ...... model of Alzheimer's disease.
@ast
Genetic inhibition of phosphor ...... model of Alzheimer's disease.
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P1433
P1476
P2093
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Genetic inhibition of phosphor ...... model of Alzheimer's disease.
@en
P2093
P2860
P304
P31
P356
10.1371/JOURNAL.PONE.0101643
P407
P433
P478
P50
P577
P5875
P698
P921
P932