Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer. - Wikidata - awgldk - TriplyDB

Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer.

Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer.

http://www.wikidata.org/entity/Q33713317

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Evolving concepts in cancer therapy through targeting sphingolipid metabolism Tamoxifen regulation of sphingolipid metabolism--Therapeutic implications The pleiotropic roles of sphingolipid signaling in autophagy Discovery and evaluation of inhibitors of human ceramidase.On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging.Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity Interdiction of sphingolipid metabolism to improve standard cancer therapies.Inhibition of human tumour prostate PC-3 cell growth by cannabinoids R(+)-Methanandamide and JWH-015: involvement of CB2 Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling.Genistein stimulates MCF-7 breast cancer cell growth by inducing acid ceramidase (ASAH1) gene expression.Acid ceramidase expression modulates the sensitivity of A375 melanoma cells to dacarbazine.Clinical utility of serum autoantibodies detected by protein microarray in melanoma Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs.Sphingolipid signaling and hematopoietic malignancies: to the rheostat and beyond.Modulation of Acid Sphingomyelinase in Melanoma Reprogrammes the Tumour Immune Microenvironment Acid ceramidase (ASAH1) is a global regulator of steroidogenic capacity and adrenocortical gene expression Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B Acid ceramidase as a therapeutic target in metastatic prostate cancer.Hyperpolarized [1-13C]dehydroascorbate MR spectroscopy in a murine model of prostate cancer: comparison with 18F-FDG PET.Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling.Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response Increased killing of SCCVII squamous cell carcinoma cells after the combination of Pc 4 photodynamic therapy and dasatinib is associated with enhanced caspase-3 activity and ceramide synthase 1 upregulation.Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy Targeting sphingolipid metabolism in head and neck cancer: rational therapeutic potentials.Metabolomics: a novel approach to early and noninvasive prostate cancer detection.Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases.The role of sphingolipids in drug metabolism and transport.New Aspects of Silibinin Stereoisomers and their 3-O-galloyl Derivatives on Cytotoxicity and Ceramide Metabolism in Hep G2 hepatocarcinoma Cell Line.Increased acid ceramidase expression depends on upregulation of androgen-dependent deubiquitinases, USP2, in a human prostate cancer cell line, LNCaP.Prostate cell lines as models for biomarker discovery: performance of current markers and the search for new biomarkers.Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse.Potential role of acid ceramidase in conversion of cytostatic to cytotoxic end-point in pancreatic cancer cells.Inhibition of acid ceramidase by a 2-substituted aminoethanol amide synergistically sensitizes prostate cancer cells to N-(4-hydroxyphenyl) retinamide.Fragment-Based Hologram QSAR Studies on a Series of 2,4-Dioxopyrimidine-1-Carboxamides As Highly Potent Inhibitors of Acid Ceramidase Autophagy is increased in prostate cancer cells overexpressing acid ceramidase and enhances resistance to C6 ceramide.The cannabinoid R+ methanandamide induces IL-6 secretion by prostate cancer PC3 cells.Ceramide metabolism determines glioma cell resistance to chemotherapy.Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells.Acid ceramidase is associated with an improved prognosis in both DCIS and invasive breast cancer.Potent inhibition of Acid ceramidase by novel B-13 analogues.

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P2860

Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer.

http://www.wikidata.org/entity/Q33713317

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2008 nî lūn-bûn

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2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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Acid ceramidase upregulation i ...... , a potential radiosensitizer.

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Molecular Therapy

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Acid ceramidase upregulation i ...... , a potential radiosensitizer.

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Aiping Bai

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Alex S McPherson

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Alicja Bielawska

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Antonio Saad

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Ayman E M Mahdy

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Christopher R Gault

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Hisham M Hammouda

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Joseph C Cheng

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P2860

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis

Human acid ceramidase is overexpressed but not mutated in prostate cancer

p53-Independent ceramide formation in human glioma cells during gamma-radiation-induced apoptosis

Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer

Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer

Phase I trial of weekly docetaxel with concurrent three-dimensional conformal radiation therapy in the treatment of unfavorable localized adenocarcinoma of the prostate.

Mass spectrometric analysis of ceramide perturbations in brain and fibroblasts of mice and human patients with peroxisomal disorders.

DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability.

The therapeutic potential of modulating the ceramide/sphingomyelin pathway

Antisense Bcl-2 sensitizes prostate cancer cells to radiation

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430-438

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10.1038/MT.2008.281

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17

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19107118

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