Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity
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Evolving concepts in cancer therapy through targeting sphingolipid metabolismThe emergence of acid ceramidase as a therapeutic target for acute myeloid leukemia.Acid ceramidase is a novel drug target for pediatric brain tumors.On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging.The identification of the endogenous ligands of natural killer T cells reveals the presence of mammalian α-linked glycosylceramides.Disruption of sphingolipid metabolism augments ceramide-induced autophagy in preeclampsia.Tissue biomarkers of drug efficacy: case studies using a MALDI-MSI workflow.Screening a Commercial Library of Pharmacologically Active Small Molecules against Staphylococcus aureus BiofilmsDiscovery of New Acid Ceramidase-Targeted Acyclic 5-Alkynyl and 5-Heteroaryl Uracil Nucleosides.Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITIONAcid ceramidase as a therapeutic target in metastatic prostate cancer.More surprises lying ahead. The endocannabinoids keep us guessing.Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloid-derived suppressor cells.Ceramidases, roles in sphingolipid metabolism and in health and disease.Fragment-Based Hologram QSAR Studies on a Series of 2,4-Dioxopyrimidine-1-Carboxamides As Highly Potent Inhibitors of Acid CeramidaseComplete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells.Specific skeletal muscle sphingolipid compounds in energy expenditure regulation and weight gain in Native Americans of Southwestern heritage.Benzoxazolone carboxamides: potent and systemically active inhibitors of intracellular acid ceramidase.3-Aminoazetidin-2-one derivatives as N-acylethanolamine acid amidase (NAAA) inhibitors suitable for systemic administration.Acid ceramidase confers radioresistance to glioblastoma cells.New Directions for Natural Killer T Cells in the Immunotherapy of Cancer.Sphingolipids and their metabolism in physiology and disease.Acid ceramidase and its inhibitors: a de novo drug target and a new class of drugs for killing glioblastoma cancer stem cells with high efficiency.Ceramide Is Metabolized to Acylceramide and Stored in Lipid Droplets.Sphingolipid pathway enzymes modulate cell fate and immune responses.Molecular Targeting of Acid Ceramidase in Glioblastoma: A Review of Its Role, Potential Treatment, and Challenges.A fluorescent probe for imaging symmetric and asymmetric cell division in neurosphere formation.Identification of an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5.Molecular Markers of Therapy-Resistant Glioblastoma and Potential Strategy to Combat Resistance.
P2860
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P2860
Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity
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2013 nî lūn-bûn
@nan
2013 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Discovery of highly potent aci ...... umor chemosensitizing activity
@ast
Discovery of highly potent aci ...... umor chemosensitizing activity
@en
Discovery of highly potent aci ...... umor chemosensitizing activity
@nl
type
label
Discovery of highly potent aci ...... umor chemosensitizing activity
@ast
Discovery of highly potent aci ...... umor chemosensitizing activity
@en
Discovery of highly potent aci ...... umor chemosensitizing activity
@nl
prefLabel
Discovery of highly potent aci ...... umor chemosensitizing activity
@ast
Discovery of highly potent aci ...... umor chemosensitizing activity
@en
Discovery of highly potent aci ...... umor chemosensitizing activity
@nl
P2093
P2860
P50
P356
P1433
P1476
Discovery of highly potent aci ...... umor chemosensitizing activity
@en
P2093
Carlos Solorzano
Chiara Pagliuca
Daniela Pizzirani
Daniele Piomelli
Natalia Realini
Tiziano Bandiera
P2860
P2888
P356
10.1038/SREP01035
P407
P577
2013-01-08T00:00:00Z
P5875
P6179
1052713297