Exploring the functional complexity of cellular proteins by protein knockout
about
Transient in utero knockout (TIUKO) of C-MYC affects late lung and intestinal development in the mouseThe ubiquitin-proteasome system as a drug target in cerebrovascular disease: therapeutic potential of proteasome inhibitors.Cullins and cancer.The maternal to zygotic transition in mammals.Engineering new protein-protein interactions on the β-propeller fold by yeast cell surface displayA recombinant chimeric protein specifically induces mutant KRAS degradation and potently inhibits pancreatic tumor growth.Engineering a single ubiquitin ligase for the selective degradation of all activated ErbB receptor tyrosine kinases.Ubiquibodies, synthetic E3 ubiquitin ligases endowed with unnatural substrate specificity for targeted protein silencingThe enzymes in ubiquitin-like post-translational modifications.The ends and means of artificially induced targeted protein degradation.Small-molecule control of intracellular protein levels through modulation of the ubiquitin proteasome systemMicroporation is an efficient method for siRNA-induced knockdown of PEX5 in HepG2 cells: evaluation of the transfection efficiency, the PEX5 mRNA and protein levels and induction of peroxisomal deficiency.Methods: A small-molecule SMASh hit.The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 proteinMaximizing target protein ablation by integration of RNAi and protein knockout.Protein knockouts in living eukaryotes using deGradFP and green fluorescent protein fusion targets.Fluorescent fusion protein knockout mediated by anti-GFP nanobody.Protein engineering strategies with potential applications for altering clinically relevant cellular pathways at the protein level.
P2860
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P2860
Exploring the functional complexity of cellular proteins by protein knockout
description
2003 nî lūn-bûn
@nan
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Exploring the functional complexity of cellular proteins by protein knockout
@ast
Exploring the functional complexity of cellular proteins by protein knockout
@en
type
label
Exploring the functional complexity of cellular proteins by protein knockout
@ast
Exploring the functional complexity of cellular proteins by protein knockout
@en
prefLabel
Exploring the functional complexity of cellular proteins by protein knockout
@ast
Exploring the functional complexity of cellular proteins by protein knockout
@en
P2093
P2860
P356
P1476
Exploring the functional complexity of cellular proteins by protein knockout
@en
P2093
Jianxuan Zhang
Ning Zheng
Pengbo Zhou
P2860
P304
14127-14132
P356
10.1073/PNAS.2233012100
P407
P577
2003-10-30T00:00:00Z