UV-damaged DNA-binding proteins are targets of CUL-4A-mediated ubiquitination and degradation
about
Simian virus 5 V protein acts as an adaptor, linking DDB1 to STAT2, to facilitate the ubiquitination of STAT1PA200, a nuclear proteasome activator involved in DNA repair.The p127 subunit (DDB1) of the UV-DNA damage repair binding protein is essential for the targeted degradation of STAT1 by the V protein of the paramyxovirus simian virus 5Circadian clock control of the cellular response to DNA damageWhat is the functional role of the thalidomide binding protein cereblon?A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machineryHepatitis B virus X protein and simian virus 5 V protein exhibit similar UV-DDB1 binding properties to mediate distinct activitiesRegulation of repair by the 26SproteasomeStructure and function of WD40 domain proteinsCullin-RING ubiquitin E3 ligase regulation by the COP9 signalosomeHepatitis B virus X protein associated with UV-DDB1 induces cell death in the nucleus and is functionally antagonized by UV-DDB2Regulation and role of Arabidopsis CUL4-DDB1A-DDB2 in maintaining genome integrity upon UV stressTumor-prone phenotype of the DDB2-deficient miceCUL4A abrogation augments DNA damage response and protection against skin carcinogenesisCUL-4A is critical for early embryonic developmentYeast deubiquitinase Ubp3 interacts with the 26 S proteasome to facilitate Rad4 degradationRegulation of TGF-β signaling, exit from the cell cycle, and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2.CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration.Xeroderma pigmentosum complementation group E protein (XPE/DDB2): purification of various complexes of XPE and analyses of their damaged DNA binding and putative DNA repair properties.DDB1 maintains genome integrity through regulation of Cdt1Damaged DNA binding protein 2 plays a role in breast cancer cell growthOther proteins interacting with XP proteins.Chromatin retention of DNA damage sensors DDB2 and XPC through loss of p97 segregase causes genotoxicity.Exploring the functional complexity of cellular proteins by protein knockoutDDB2 suppresses tumorigenicity by limiting the cancer stem cell population in ovarian cancer.Nedd8 on cullin: building an expressway to protein destruction.Regulation of nucleotide excision repair by UV-DDB: prioritization of damage recognition to internucleosomal DNAThe emerging role of the COP9 signalosome in cancer.CUL-4A stimulates ubiquitylation and degradation of the HOXA9 homeodomain protein.Cullins and cancer.Composition and assembly of STAT-targeting ubiquitin ligase complexes: paramyxovirus V protein carboxyl terminus is an oligomerization domain.The hepatitis B virus X protein sensitizes HepG2 cells to UV light-induced DNA damage.Molecules and mechanisms controlling the active DNA demethylation of the mammalian zygotic genome.The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites.The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability.Structural assembly of cullin-RING ubiquitin ligase complexes.Alternative splicing tends to avoid partial removals of protein-protein interaction sites.Regulation of DNA damage response pathways by the cullin-RING ubiquitin ligasesMechanism of immunomodulatory drugs' action in the treatment of multiple myeloma.Oncogenic aberrations of cullin-dependent ubiquitin ligases.
P2860
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P2860
UV-damaged DNA-binding proteins are targets of CUL-4A-mediated ubiquitination and degradation
description
2001 nî lūn-bûn
@nan
2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
name
UV-damaged DNA-binding protein ...... ubiquitination and degradation
@ast
UV-damaged DNA-binding protein ...... ubiquitination and degradation
@en
UV-damaged DNA-binding protein ...... ubiquitination and degradation
@en-gb
UV-damaged DNA-binding protein ...... ubiquitination and degradation
@nl
type
label
UV-damaged DNA-binding protein ...... ubiquitination and degradation
@ast
UV-damaged DNA-binding protein ...... ubiquitination and degradation
@en
UV-damaged DNA-binding protein ...... ubiquitination and degradation
@en-gb
UV-damaged DNA-binding protein ...... ubiquitination and degradation
@nl
prefLabel
UV-damaged DNA-binding protein ...... ubiquitination and degradation
@ast
UV-damaged DNA-binding protein ...... ubiquitination and degradation
@en
UV-damaged DNA-binding protein ...... ubiquitination and degradation
@en-gb
UV-damaged DNA-binding protein ...... ubiquitination and degradation
@nl
P2093
P2860
P921
P356
P1476
UV-damaged DNA-binding protein ...... ubiquitination and degradation
@en
P2093
P2860
P304
P356
10.1074/JBC.M106808200
P407
P577
2001-12-21T00:00:00Z