Prediction of repeat-dose occupancy from single-dose data: characterisation of the relationship between plasma pharmacokinetics and brain target occupancy.
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The development, past achievements, and future directions of brain PETA small-animal pharmacokinetic/pharmacodynamic PET study of central serotonin 1A receptor occupancy by a potential therapeutic agent for overactive bladderPositron emission tomography molecular imaging for drug development.Evaluation of the agonist PET radioligand [¹¹C]GR103545 to image kappa opioid receptor in humans: kinetic model selection, test-retest reproducibility and receptor occupancy by the antagonist PF-04455242.A pharmacokinetic PET study of NK₁ receptor occupancy.Receptor Occupancy of the κ-Opioid Antagonist LY2456302 Measured with Positron Emission Tomography and the Novel Radiotracer 11C-LY2795050.Pharmacological differentiation of opioid receptor antagonists by molecular and functional imaging of target occupancy and food reward-related brain activation in humans.An evaluation of the brain distribution of [(11)C]GSK1034702, a muscarinic-1 (M 1) positive allosteric modulator in the living human brain using positron emission tomography.Predicting brain occupancy from plasma levels using PET: superiority of combining pharmacokinetics with pharmacodynamics while modeling the relationshipPharmacokinetic modeling of P-glycoprotein function at the rat and human blood-brain barriers studied with (R)-[11C]verapamil positron emission tomography.Kinetic analysis of drug-target interactions with PET for characterization of pharmacological hysteresis.Pharmacokinetic-pharmacodynamic modeling in acute and chronic pain: an overview of the recent literature.Applications of imaging biomarkers in the early clinical development of central nervous system therapeutic agents.Preclinical to clinical translation of CNS transporter occupancy of TD-9855, a novel norepinephrine and serotonin reuptake inhibitor.Characterising the plasma-target occupancy relationship of the neurokinin antagonist GSK1144814 with PET.Quantitative PET Imaging in Drug Development: Estimation of Target Occupancy.Occupancy of Norepinephrine Transporter by Duloxetine in Human Brains Measured by Positron Emission Tomography with (S,S)-[18F]FMeNER-D2.Determination of dopamine D₂ receptor occupancy by lurasidone using positron emission tomography in healthy male subjects.
P2860
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P2860
Prediction of repeat-dose occupancy from single-dose data: characterisation of the relationship between plasma pharmacokinetics and brain target occupancy.
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Prediction of repeat-dose occu ...... cs and brain target occupancy.
@ast
Prediction of repeat-dose occu ...... cs and brain target occupancy.
@en
type
label
Prediction of repeat-dose occu ...... cs and brain target occupancy.
@ast
Prediction of repeat-dose occu ...... cs and brain target occupancy.
@en
prefLabel
Prediction of repeat-dose occu ...... cs and brain target occupancy.
@ast
Prediction of repeat-dose occu ...... cs and brain target occupancy.
@en
P2093
P2860
P356
P1476
Prediction of repeat-dose occu ...... cs and brain target occupancy.
@en
P2093
Carmine Marzano
Cristian A Salinas
Graham E Searle
Jasper van der Aart
Javaad J Ahmad
Julien A R Barletta
Marc A Laruelle
Richard R Reiley
Roger N Gunn
Sabina Pampols-Maso
P2860
P304
P356
10.1038/JCBFM.2010.175
P577
2010-10-13T00:00:00Z