Pharmacokinetic-pharmacodynamic modelling: history and perspectives.
about
Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug actionNovel in vitro and mathematical models for the prediction of chemical toxicityPharmacokinetic-pharmacodynamic modelling of opioids in healthy human volunteers. a minireviewAddressing human variability in next-generation human health risk assessments of environmental chemicalsAn Algorithm and R Program for Fitting and Simulation of Pharmacokinetic and Pharmacodynamic Data.Prediction of repeat-dose occupancy from single-dose data: characterisation of the relationship between plasma pharmacokinetics and brain target occupancy.Using physiologically-based pharmacokinetic-guided "body-on-a-chip" systems to predict mammalian response to drug and chemical exposureOpportunities and limits of cell-based assay miniaturization in drug discovery.Concepts and challenges in quantitative pharmacology and model-based drug development.Interpreting population pharmacokinetic-pharmacodynamic analyses - a clinical viewpoint.Pharmacokinetics and pharmacodynamics of AZD6244 (ARRY-142886) in tumor-bearing nude mice.Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration.Monitoring drug therapy.A survey of population analysis methods and software for complex pharmacokinetic and pharmacodynamic models with examplesKinetic analysis of drug-target interactions with PET for characterization of pharmacological hysteresis.Applications of quantitative pharmacodynamic effect markers in drug target identification and therapy developmentMicrofluidics for drug discovery and development: from target selection to product lifecycle management.Quantitative Systems Pharmacology: A Framework for Context.Integration of in silico and in vitro platforms for pharmacokinetic-pharmacodynamic modeling.Understanding the time course of pharmacological effect: a PKPD approach.The Øie-Tozer model of drug distribution and its suitability for drugs with different pharmacokinetic behavior.Physiologically based pharmacokinetic tissue compartment model selection in drug development and risk assessmentThe current role of model-based drug development.Application of microdialysis for pharmacokinetic-pharmacodynamic modelling.Population pharmacometrics in support of analgesics studies.Gap analysis of pharmacokinetics and pharmacodynamics in burn patients: a review.Using Multiple Pharmacovigilance Models Improves the Timeliness of Signal Detection in Simulated Prospective Surveillance.Pharmacotherapy in pediatric epilepsy: from trial and error to rational drug and dose selection - a long way to go.Bacterial fitness shapes the population dynamics of antibiotic-resistant and -susceptible bacteria in a model of combined antibiotic and anti-virulence treatment.Discovery DMPK: changing paradigms in the eighties, nineties and noughties.Basic PK/PD principles of drug effects in circular/proliferative systems for disease modelling.Fractional dynamics pharmacokinetics-pharmacodynamic models.Establishing Good Practices for Exposure-Response Analysis of Clinical Endpoints in Drug Development.Modelling Drug Abuse Epidemics in the Presence of Limited Rehabilitation Capacity.Comparison of alternative models for linking drug exposure with adverse effects.Assessing the cumulative effects of exposure to selected benzodiazepines on the risk of fall-related injuries in the elderly.A population pharmacokinetic and pharmacodynamic study of a peripheral κ-opioid receptor agonist CR665 and oxycodone.Increased sensitivity to diltiazem hypotensive effect in an experimental model of high-renin hypertension.Spatiotemporal pharmacodynamics of meropenem- and tobramycin-treated Pseudomonas aeruginosa biofilms.Performance of the marginal structural cox model for estimating individual and joined effects of treatments given in combination.
P2860
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P2860
Pharmacokinetic-pharmacodynamic modelling: history and perspectives.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Pharmacokinetic-pharmacodynamic modelling: history and perspectives.
@ast
Pharmacokinetic-pharmacodynamic modelling: history and perspectives.
@en
type
label
Pharmacokinetic-pharmacodynamic modelling: history and perspectives.
@ast
Pharmacokinetic-pharmacodynamic modelling: history and perspectives.
@en
prefLabel
Pharmacokinetic-pharmacodynamic modelling: history and perspectives.
@ast
Pharmacokinetic-pharmacodynamic modelling: history and perspectives.
@en
P2860
P1476
Pharmacokinetic-pharmacodynamic modelling: history and perspectives.
@en
P2093
Davide Verotta
P2860
P2888
P304
P356
10.1007/S10928-005-9002-0
P577
2006-01-11T00:00:00Z