Structures of discoidal high density lipoproteins: a combined computational-experimental approach
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High-Density Lipoprotein, Lecithin: Cholesterol Acyltransferase, and AtherosclerosisStructural Insights into High Density Lipoprotein: Old Models and New FactsNew insights into the determination of HDL structure by apolipoproteins: Thematic review series: high density lipoprotein structure, function, and metabolismCrystal Structure of C-terminal Truncated Apolipoprotein A-I Reveals the Assembly of High Density Lipoprotein (HDL) by DimerizationSequence conservation of apolipoprotein A-I affords novel insights into HDL structure-functionIsolation, characterization, and stability of discretely-sized nanolipoprotein particles assembled with apolipophorin-IIIA model of lipid-free apolipoprotein A-I revealed by iterative molecular dynamics simulationMD simulations suggest important surface differences between reconstituted and circulating spherical HDL.Congruency between biophysical data from multiple platforms and molecular dynamics simulation of the double-super helix model of nascent high-density lipoprotein.Exchange of apolipoprotein A-I between lipid-associated and lipid-free states: a potential target for oxidative generation of dysfunctional high density lipoproteinsElliptical structure of phospholipid bilayer nanodiscs encapsulated by scaffold proteins: casting the roles of the lipids and the proteinMorphology and structure of lipoproteins revealed by an optimized negative-staining protocol of electron microscopy.Assessment of the validity of the double superhelix model for reconstituted high density lipoproteins: a combined computational-experimental approach.Structure of apolipoprotein A-I N terminus on nascent high density lipoproteins.Non-vesicular transfer of membrane proteins from nanoparticles to lipid bilayers.The low resolution structure of ApoA1 in spherical high density lipoprotein revealed by small angle neutron scattering.Atomistic MD simulation reveals the mechanism by which CETP penetrates into HDL enabling lipid transfer from HDL to CETPApolipoprotein A-I structural organization in high-density lipoproteins isolated from human plasma."Sticky" and "promiscuous", the yin and yang of apolipoprotein A-I termini in discoidal high-density lipoproteins: a combined computational-experimental approach.Conformational transitions in the membrane scaffold protein of phospholipid bilayer nanodiscsSurface Density-Induced Pleating of a Lipid Monolayer Drives Nascent High-Density Lipoprotein Assembly.A novel truncated form of apolipoprotein A-I transported by dense LDL is increased in diabetic patients.Apolipoprotein A-I helical structure and stability in discoidal high-density lipoprotein (HDL) particles by hydrogen exchange and mass spectrometry.Validation of previous computer models and MD simulations of discoidal HDL by a recent crystal structure of apoA-I.Human paraoxonase 1 overexpression in mice stimulates HDL cholesterol efflux and reverse cholesterol transport.Lipoprotein hydrophobic core lipids are partially extruded to surface in smaller HDL: "Herniated" HDL, a common feature in diabetesCrystal structure of Δ(185-243)ApoA-I suggests a mechanistic framework for the protein adaptation to the changing lipid load in good cholesterol: from flatland to sphereland via double belt, belt buckle, double hairpin and trefoil/tetrafoilHigh-density lipoproteins and the immune systemThe low-resolution structure of nHDL reconstituted with DMPC with and without cholesterol reveals a mechanism for particle expansion.Rotational and hinge dynamics of discoidal high density lipoproteins probed by interchain disulfide bond formationPreparation and Characterization of Stable α-Synuclein Lipoprotein Particlesα-Synuclein oligomers with broken helical conformation form lipoprotein nanoparticles.Factors controlling nascent high-density lipoprotein particle heterogeneity: ATP-binding cassette transporter A1 activity and cell lipid and apolipoprotein AI availabilityMyeloperoxidase, paraoxonase-1, and HDL form a functional ternary complexFolded functional lipid-poor apolipoprotein A-I obtained by heating of high-density lipoproteins: relevance to high-density lipoprotein biogenesis.Conservation of apolipoprotein A-I's central domain structural elements upon lipid association on different high-density lipoprotein subclasses.Probing the C-terminal domain of lipid-free apoA-I demonstrates the vital role of the H10B sequence repeat in HDL formation.High throughput quantification of apolipoproteins A-I and B-100 by isotope dilution MS targeting fast trypsin releasable peptides without reduction and alkylation.Sequence-specific apolipoprotein A-I effects on lecithin:cholesterol acyltransferase activity.Paraoxonase 1-treated oxLDL promotes cholesterol efflux from macrophages by stimulating the PPARγ-LXRα-ABCA1 pathway.
P2860
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P2860
Structures of discoidal high density lipoproteins: a combined computational-experimental approach
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Structures of discoidal high d ...... tational-experimental approach
@ast
Structures of discoidal high d ...... tational-experimental approach
@en
type
label
Structures of discoidal high d ...... tational-experimental approach
@ast
Structures of discoidal high d ...... tational-experimental approach
@en
prefLabel
Structures of discoidal high d ...... tational-experimental approach
@ast
Structures of discoidal high d ...... tational-experimental approach
@en
P2093
P2860
P356
P1476
Structures of discoidal high d ...... tational-experimental approach
@en
P2093
James C Patterson
Jere P Segrest
Jianguo Chen
Martin K Jones
W Gray Jerome
P2860
P304
P356
10.1074/JBC.M109.069914
P407
P577
2009-11-30T00:00:00Z