Niemann-Pick C1 functions independently of Niemann-Pick C2 in the initial stage of retrograde transport of membrane-impermeable lysosomal cargo.
about
Ebola virus entry requires the cholesterol transporter Niemann-Pick C1The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunctionMolecular pathways for intracellular cholesterol accumulation: common pathogenic mechanisms in Niemann-Pick disease Type C and cystic fibrosisLoss of Niemann-Pick C1 or C2 protein results in similar biochemical changes suggesting that these proteins function in a common lysosomal pathwayProtein replacement therapy partially corrects the cholesterol-storage phenotype in a mouse model of Niemann-Pick type C2 diseaseNiemann-Pick C disease and mobilization of lysosomal cholesterol by cyclodextrinCharacteristics of highly polymorphic segmental copy-number variations observed in Japanese by BAC-array-CGHSensitivity to lysosome-dependent cell death is directly regulated by lysosomal cholesterol contentSomatic cell plasticity and Niemann-Pick type C2 protein: fibroblast activation.Cathepsin B & L are not required for ebola virus replicationLoss of AP-5 results in accumulation of aberrant endolysosomes: defining a new type of lysosomal storage diseaseThe Niemann-Pick C1 Inhibitor NP3.47 Enhances Gene Silencing Potency of Lipid Nanoparticles Containing siRNA.APP overexpression in the absence of NPC1 exacerbates metabolism of amyloidogenic proteins of Alzheimer's disease.Potential vaccines and post-exposure treatments for filovirus infections.Normalizing glycosphingolipids restores function in CD4+ T cells from lupus patients.All-trans retinoic acid-triggered antimicrobial activity against Mycobacterium tuberculosis is dependent on NPC2.Defective cholesterol trafficking in Niemann-Pick C-deficient cells.Complex lipid trafficking in Niemann-Pick disease type C.Identification of lysosomal Npc1-binding proteins: Cathepsin D activity is regulated by NPC1.Cardiac and skeletal muscles show molecularly distinct responses to cancer cachexia.Niemann-Pick Type C2 protein contributes to the transport of endosomal cholesterol to mitochondria without interacting with NPC1.Multiple Surface Regions on the Niemann-Pick C2 Protein Facilitate Intracellular Cholesterol Transport.Unesterified cholesterol accumulation in late endosomes/lysosomes causes neurodegeneration and is prevented by driving cholesterol export from this compartment.Involvement of cathepsins B and L in inflammation and cholesterol trafficking protein NPC2 secretion in macrophages.The Effects of Extracellular Serum Concentration on APP Processing in Npc1-Deficient APP-Overexpressing N2a Cells.Geranylgeranyl pyrophosphate is crucial for neuronal survival but has no special role in Purkinje cell degeneration in Niemann Pick type C1 disease.Recent neuroimaging, neurophysiological, and neuropathological advances for the understanding of NPC.LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis
P2860
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P2860
Niemann-Pick C1 functions independently of Niemann-Pick C2 in the initial stage of retrograde transport of membrane-impermeable lysosomal cargo.
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Niemann-Pick C1 functions inde ...... e-impermeable lysosomal cargo.
@ast
Niemann-Pick C1 functions inde ...... e-impermeable lysosomal cargo.
@en
type
label
Niemann-Pick C1 functions inde ...... e-impermeable lysosomal cargo.
@ast
Niemann-Pick C1 functions inde ...... e-impermeable lysosomal cargo.
@en
prefLabel
Niemann-Pick C1 functions inde ...... e-impermeable lysosomal cargo.
@ast
Niemann-Pick C1 functions inde ...... e-impermeable lysosomal cargo.
@en
P2860
P356
P1476
Niemann-Pick C1 functions inde ...... e-impermeable lysosomal cargo.
@en
P2093
Jeffrey P Krise
Stephen D B Goldman
P2860
P304
P356
10.1074/JBC.M109.037622
P407
P577
2009-12-10T00:00:00Z