Normal gating of CFTR requires ATP binding to both nucleotide-binding domains and hydrolysis at the second nucleotide-binding domain.
about
The ABC protein turned chloride channel whose failure causes cystic fibrosisRequirements for Efficient Correction of ΔF508 CFTR Revealed by Analyses of Evolved SequencesRobust Stimulation of W1282X-CFTR Channel Activity by a Combination of Allosteric ModulatorsATP and AMP mutually influence their interaction with the ATP-binding cassette (ABC) adenylate kinase cystic fibrosis transmembrane conductance regulator (CFTR) at separate binding sites.ATP-independent CFTR channel gating and allosteric modulation by phosphorylation.Interactions of alamethicin with model cell membranes investigated using sum frequency generation vibrational spectroscopy in real time in situThe H-loop in the second nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator is required for efficient chloride channel closingADP inhibits function of the ABC transporter cystic fibrosis transmembrane conductance regulator via its adenylate kinase activity.Conserved allosteric hot spots in the transmembrane domains of cystic fibrosis transmembrane conductance regulator (CFTR) channels and multidrug resistance protein (MRP) pumps.Sequences in the nonconsensus nucleotide-binding domain of ABCG5/ABCG8 required for sterol transportMutant cycles at CFTR's non-canonical ATP-binding site support little interface separation during gatingThermally unstable gating of the most common cystic fibrosis mutant channel (ΔF508): "rescue" by suppressor mutations in nucleotide binding domain 1 and by constitutive mutations in the cytosolic loops.Mutating the Conserved Q-loop Glutamine 1291 Selectively Disrupts Adenylate Kinase-dependent Channel Gating of the ATP-binding Cassette (ABC) Adenylate Kinase Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and Reduces Channel Function inObserving a model ion channel gating action in model cell membranes in real time in situ: membrane potential change induced alamethicin orientation change.Adenylate kinase activity in ABC transporters.Deletion of Phenylalanine 508 in the First Nucleotide-binding Domain of the Cystic Fibrosis Transmembrane Conductance Regulator Increases Conformational Exchange and Inhibits Dimerization.G551D and G1349D, two CF-associated mutations in the signature sequences of CFTR, exhibit distinct gating defectsDemonstration of phosphoryl group transfer indicates that the ATP-binding cassette (ABC) transporter cystic fibrosis transmembrane conductance regulator (CFTR) exhibits adenylate kinase activityInsight in eukaryotic ABC transporter function by mutation analysis.Update in cystic fibrosis 2005Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins.Converting nonhydrolyzable nucleotides to strong cystic fibrosis transmembrane conductance regulator (CFTR) agonists by gain of function (GOF) mutationsA mutation in CFTR modifies the effects of the adenylate kinase inhibitor Ap5A on channel gating.CLC-0 and CFTR: chloride channels evolved from transporters.The deviant ATP-binding site of the multidrug efflux pump Pdr5 plays an active role in the transport cycle.ATP binding to two sites is necessary for dimerization of nucleotide-binding domains of ABC proteins.Stabilization of a nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator yields insight into disease-causing mutations.Hydrogen sulfide stimulates CFTR in Xenopus oocytes by activation of the cAMP/PKA signalling axisTrimethylangelicin promotes the functional rescue of mutant F508del CFTR protein in cystic fibrosis airway cells.Interference with ubiquitination in CFTR modifies stability of core glycosylated and cell surface pools.Ethanol and its non-oxidative metabolites profoundly inhibit CFTR function in pancreatic epithelial cells which is prevented by ATP supplementation.Restoration of W1282X CFTR activity by enhanced expression.Role of GSH in estrone sulfate binding and translocation by the multidrug resistance protein 1 (MRP1/ABCC1).The cystic fibrosis transmembrane conductance regulator is an extracellular chloride sensor.The two ATP binding sites of cystic fibrosis transmembrane conductance regulator (CFTR) play distinct roles in gating kinetics and energetics.The Walker B motif of the second nucleotide-binding domain (NBD2) of CFTR plays a key role in ATPase activity by the NBD1-NBD2 heterodimer.Ligand-driven vectorial folding of ribosome-bound human CFTR NBD1Cystic fibrosis transmembrane conductance regulator in the gills of the climbing perch, Anabas testudineus, is involved in both hypoosmotic regulation during seawater acclimation and active ammonia excretion during ammonia exposure.Effects of protein sources and levels in antibiotic-free diets on diarrhea, intestinal morphology, and expression of tight junctions in weaned piglets.Molecular dynamics simulation study on the structural instability of the most common cystic fibrosis-associated mutant ΔF508-CFTR.
P2860
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P2860
Normal gating of CFTR requires ATP binding to both nucleotide-binding domains and hydrolysis at the second nucleotide-binding domain.
description
2004 nî lūn-bûn
@nan
2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Normal gating of CFTR requires ...... ond nucleotide-binding domain.
@ast
Normal gating of CFTR requires ...... ond nucleotide-binding domain.
@en
type
label
Normal gating of CFTR requires ...... ond nucleotide-binding domain.
@ast
Normal gating of CFTR requires ...... ond nucleotide-binding domain.
@en
prefLabel
Normal gating of CFTR requires ...... ond nucleotide-binding domain.
@ast
Normal gating of CFTR requires ...... ond nucleotide-binding domain.
@en
P2093
P2860
P356
P1476
Normal gating of CFTR requires ...... ond nucleotide-binding domain.
@en
P2093
Allan L Berger
Michael J Welsh
Mutsuhiro Ikuma
P2860
P304
P356
10.1073/PNAS.0408575102
P577
2004-12-27T00:00:00Z