ATP-independent CFTR channel gating and allosteric modulation by phosphorylation. - Wikidata - awgldk - TriplyDB

ATP-independent CFTR channel gating and allosteric modulation by phosphorylation.

ATP-independent CFTR channel gating and allosteric modulation by phosphorylation.

http://www.wikidata.org/entity/Q33734745

about

Allosteric coupling between the intracellular coupling helix 4 and regulatory sites of the first nucleotide-binding domain of CFTR Robust Stimulation of W1282X-CFTR Channel Activity by a Combination of Allosteric Modulators Obligate coupling of CFTR pore opening to tight nucleotide-binding domain dimerization Curcumin and genistein: the combined effects on disease-associated CFTR mutants and their clinical implications Conserved allosteric hot spots in the transmembrane domains of cystic fibrosis transmembrane conductance regulator (CFTR) channels and multidrug resistance protein (MRP) pumps.Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATP-independent manner.Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation.State-dependent regulation of cystic fibrosis transmembrane conductance regulator (CFTR) gating by a high affinity Fe3+ bridge between the regulatory domain and cytoplasmic loop 3.An electrostatic interaction at the tetrahelix bundle promotes phosphorylation-dependent cystic fibrosis transmembrane conductance regulator (CFTR) channel opening.The inhibition mechanism of non-phosphorylated Ser768 in the regulatory domain of cystic fibrosis transmembrane conductance regulator Full-open and closed CFTR channels, with lateral tunnels from the cytoplasm and an alternative position of the F508 region, as revealed by molecular dynamics.Thermally unstable gating of the most common cystic fibrosis mutant channel (ΔF508): "rescue" by suppressor mutations in nucleotide binding domain 1 and by constitutive mutations in the cytosolic loops.Purification of CFTR for mass spectrometry analysis: identification of palmitoylation and other post-translational modifications.Murine and human CFTR exhibit different sensitivities to CFTR potentiators.Regulation of activation and processing of the cystic fibrosis transmembrane conductance regulator (CFTR) by a complex electrostatic interaction between the regulatory domain and cytoplasmic loop 3.The CFTR ion channel: gating, regulation, and anion permeation Channel Gating Regulation by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) First Cytosolic Loop.Long-range coupling between the extracellular gates and the intracellular ATP binding domains of multidrug resistance protein pumps and cystic fibrosis transmembrane conductance regulator channels Dynamics intrinsic to cystic fibrosis transmembrane conductance regulator function and stability Converting nonhydrolyzable nucleotides to strong cystic fibrosis transmembrane conductance regulator (CFTR) agonists by gain of function (GOF) mutations Nonequilibrium gating of CFTR on an equilibrium theme.S-palmitoylation regulates biogenesis of core glycosylated wild-type and F508del CFTR in a post-ER compartment.Catalyst-like modulation of transition states for CFTR channel opening and closing: new stimulation strategy exploits nonequilibrium gating.A unified view of cystic fibrosis transmembrane conductance regulator (CFTR) gating: combining the allosterism of a ligand-gated channel with the enzymatic activity of an ATP-binding cassette (ABC) transporter Functional Rescue of F508del-CFTR Using Small Molecule Correctors Repairing mutated proteins--development of small molecules targeting defects in the cystic fibrosis transmembrane conductance regulator.Conformational changes opening and closing the CFTR chloride channel: insights from cysteine scanning mutagenesis.Mechanistic insight into the heme-independent interplay between iron and carbon monoxide in CFTR and Slo1 BKCa channels.Structural Changes Fundamental to Gating of the Cystic Fibrosis Transmembrane Conductance Regulator Anion Channel Pore.Functional Architecture of the Cytoplasmic Entrance to the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Pore.Current insights into the role of PKA phosphorylation in CFTR channel activity and the pharmacological rescue of cystic fibrosis disease-causing mutants.Revertant mutants modify, but do not rescue, the gating defect of the cystic fibrosis mutant G551D-CFTR.Role of the juxtamembrane region of cytoplasmic loop 3 in the gating and conductance of the cystic fibrosis transmembrane conductance regulator chloride channel.Regulatory insertion removal restores maturation, stability and function of DeltaF508 CFTR CFTR is a mechanosensitive anion channel: a real stretch?ATP is dispensable for both miRNA- and Smaug-mediated deadenylation reactions.Sites associated with Kalydeco binding on human Cystic Fibrosis Transmembrane Conductance Regulator revealed by Hydrogen/Deuterium Exchange.Molecular dynamics simulation study on the structural instability of the most common cystic fibrosis-associated mutant ΔF508-CFTR.

P2860

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P2860

ATP-independent CFTR channel gating and allosteric modulation by phosphorylation.

http://www.wikidata.org/entity/Q33734745

description

2010 nî lūn-bûn

@nan

2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

ATP-independent CFTR channel gating and allosteric modulation by phosphorylation.

@ast

ATP-independent CFTR channel gating and allosteric modulation by phosphorylation.

@en

type

label

ATP-independent CFTR channel gating and allosteric modulation by phosphorylation.

@ast

ATP-independent CFTR channel gating and allosteric modulation by phosphorylation.

@en

prefLabel

ATP-independent CFTR channel gating and allosteric modulation by phosphorylation.

@ast

ATP-independent CFTR channel gating and allosteric modulation by phosphorylation.

@en

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PNAS.0913001107

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

ATP-independent CFTR channel gating and allosteric modulation by phosphorylation.

@en

P2093

Ge Li

http://www.w3.org/2001/XMLSchema#string

Guangyu Wang

http://www.w3.org/2001/XMLSchema#string

Jianping Wu

http://www.w3.org/2001/XMLSchema#string

Karen Bernard

http://www.w3.org/2001/XMLSchema#string

Kevin L Kirk

http://www.w3.org/2001/XMLSchema#string

Mark O Bevensee

http://www.w3.org/2001/XMLSchema#string

Wei Wang

http://www.w3.org/2001/XMLSchema#string

P2860

Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding

Flexibility in the ABC transporter MsbA: Alternating access with a twist.

Structural basis of trans-inhibition in a molybdate/tungstate ABC transporter

ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

ABC transporters: from microorganisms to man

Structure of a bacterial multidrug ABC transporter

Normal gating of CFTR requires ATP binding to both nucleotide-binding domains and hydrolysis at the second nucleotide-binding domain.

ADP inhibits function of the ABC transporter cystic fibrosis transmembrane conductance regulator via its adenylate kinase activity.

Allosteric mechanisms of signal transduction.

Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion.

P304

3888-3893

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scholarly article

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10.1073/PNAS.0913001107

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P407

P433

8

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P478

107

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P577

2010-02-03T00:00:00Z

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41408568

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20133716

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P921

phosphorylation

P932

2840504

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