Retroviral recombination in vivo: viral replication patterns and genetic structure of simian immunodeficiency virus (SIV) populations in rhesus macaques after simultaneous or sequential intravaginal inoculation with SIVmac239Deltavpx/Deltavpr and SI

Retroviral recombination in vivo: viral replication patterns and genetic structure of simian immunodeficiency virus (SIV) populations in rhesus macaques after simultaneous or sequential intravaginal inoculation with SIVmac239Deltavpx/Deltavpr and SI

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http://www.wikidata.org/entity/Q33724189

Q33724189

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High Frequency of Genetic Recombination Is a Common Feature of Primate Lentivirus Replication Preclinical assessment of HIV vaccines and microbicides by repeated low-dose virus challenges.An antiretroviral/zinc combination gel provides 24 hours of complete protection against vaginal SHIV infection in macaques Protection of macaques with diverse MHC genotypes against a heterologous SIV by vaccination with a deglycosylated live-attenuated SIV.Multi-low-dose mucosal simian immunodeficiency virus SIVmac239 challenge of cynomolgus macaques immunized with "hyperattenuated" SIV constructs.Efficient entry inhibition of human and nonhuman primate immunodeficiency virus by cell surface-expressed gp41-derived peptides.Is an HIV vaccine possible?A limited number of simian immunodeficiency virus (SIV) env variants are transmitted to rhesus macaques vaginally inoculated with SIVmac251.The Toll-like receptor 7 (TLR7) agonist, imiquimod, and the TLR9 agonist, CpG ODN, induce antiviral cytokines and chemokines but do not prevent vaginal transmission of simian immunodeficiency virus when applied intravaginally to rhesus macaques.Relative replication capacity of phenotypic SIV variants during primary infections differs with route of inoculation.Quantification of unintegrated HIV-1 DNA at the single cell level in vivo.Retroviral vectors for analysis of viral mutagenesis and recombination.HIV-1 pathogenesis: the virus.Macaques vaccinated with live-attenuated SIV control replication of heterologous virus.SHIV infection protects against heterologous pathogenic SHIV challenge in macaques: a gold-standard for HIV-1 vaccine development?Comparison of the replication and persistence of simian-human immunodeficiency viruses expressing Vif proteins with mutation of the SLQYLA or HCCH domains in macaques.Latent HIV-1 can be reactivated by cellular superinfection in a Tat-dependent manner, which can lead to the emergence of multidrug-resistant recombinant viruses.Stable multi-infection of splenocytes during SIV infection--the basis for continuous recombination.

P2860

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P2860

Retroviral recombination in vivo: viral replication patterns and genetic structure of simian immunodeficiency virus (SIV) populations in rhesus macaques after simultaneous or sequential intravaginal inoculation with SIVmac239Deltavpx/Deltavpr and SI

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http://www.wikidata.org/entity/Q33724189

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2005 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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