Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development.
about
Genetically Engineered Mouse Models Reveal the Importance of Proteases as Osteoarthritis Drug TargetsMatrix metalloproteinases and the regulation of tissue remodellingThe accumulation of intracellular ITEGE and DIPEN neoepitopes in bovine articular chondrocytes is mediated by CD44 internalization of hyaluronan.ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan.Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repairEvidence for lysosomal exocytosis and release of aggrecan-degrading hydrolases from hypertrophic chondrocytes, in vitro and in vivo.Hyaluronan as a therapeutic target in human diseasesMast cell-restricted, tetramer-forming tryptases induce aggrecanolysis in articular cartilage by activating matrix metalloproteinase-3 and -13 zymogensBiochemical markers and the FDA Critical Path: how biomarkers may contribute to the understanding of pathophysiology and provide unique and necessary tools for drug development.Matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs in non-neoplastic diseases.Ellis-van Creveld Syndrome in Grey Alpine Cattle: Morphologic, Immunophenotypic, and Molecular Characterization.Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activityN-linked keratan sulfate in the aggrecan interglobular domain potentiates aggrecanase activity.Aggrecanase cleavage in juvenile idiopathic arthritis patients is minimally detected in the aggrecan interglobular domain but robust at the aggrecan C-terminus.Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage.An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2.Bone growth retardation in mouse embryos expressing human collagenase 1.
P2860
Q26822238-781E6D66-93D4-48FE-BB50-09C6DFBE6B85Q29618747-A3CC8159-6895-4853-9368-B4420379F280Q34569288-85FA4CB1-1347-49D6-8959-09E86A3E6A40Q34606492-7659DB91-1414-4238-A497-65F282AA4C67Q35785741-C53729AE-CB3F-48A0-A9B1-10661AAE5A39Q36432069-CAFFC9DD-71C7-4B82-9D4F-FC48B063897CQ36578627-1C9923A5-D007-4AC4-8DD1-BCFB8D842F7AQ37055039-5BD4A168-4510-4967-9A21-21F3797DA498Q37462448-FD5E6817-74BA-4BE9-847B-04418F850CA0Q37769281-DED17999-B0E9-4BEA-9582-102396684DE7Q40832568-7ADB6DBE-EF97-4DBD-8DC1-FB55A4BD83E8Q40886514-3A007039-A865-41DB-BA7A-A209BFC2C1D5Q46453456-E14792E5-938B-4D53-B757-EC6535865315Q50242889-823A02A4-D841-4BFA-892C-4DD1D5B3CD37Q50280462-F6101932-CC19-4AF4-9A81-6015DAA04509Q52725144-5CBB6382-DBF3-488E-A811-8084DFE06C9FQ53538571-9323D1C6-BB6B-472E-B062-C197E5669C03
P2860
Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development.
description
2005 nî lūn-bûn
@nan
2005 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Matrix metalloproteinases are ...... eletal growth and development.
@ast
Matrix metalloproteinases are ...... eletal growth and development.
@en
type
label
Matrix metalloproteinases are ...... eletal growth and development.
@ast
Matrix metalloproteinases are ...... eletal growth and development.
@en
prefLabel
Matrix metalloproteinases are ...... eletal growth and development.
@ast
Matrix metalloproteinases are ...... eletal growth and development.
@en
P2093
P2860
P50
P1476
Matrix metalloproteinases are ...... eletal growth and development.
@en
P2093
Clare T Meeker
Natalie A Sims
Rosalind M Hembry
Sue B Golub
P2860
P304
P356
10.1128/MCB.25.8.3388-3399.2005
P407
P577
2005-04-01T00:00:00Z