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Membrane-type 1 MMP (MMP-14) cleaves at three sites in the aggrecan interglobular domainMatrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development.ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro.Evidence for lysosomal exocytosis and release of aggrecan-degrading hydrolases from hypertrophic chondrocytes, in vitro and in vivo.A Disintegrin and Metalloproteinase with Thrombospondin Motifs-5 (ADAMTS-5) Forms Catalytically Active OligomersBioactivity in an Aggrecan 32-mer Fragment Is Mediated via Toll-like Receptor 2.Perlecan from human epithelial cells is a hybrid heparan/chondroitin/keratan sulfate proteoglycan.N-linked keratan sulfate in the aggrecan interglobular domain potentiates aggrecanase activity.Aggrecanase cleavage in juvenile idiopathic arthritis patients is minimally detected in the aggrecan interglobular domain but robust at the aggrecan C-terminus.Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage.Cytokine-induced increases in ADAMTS-4 messenger RNA expression do not lead to increased aggrecanase activity in ADAMTS-5-deficient mice.Neoepitope Antibodies Against MMP-Cleaved and Aggrecanase-Cleaved AggrecanRecombinant human inteleukin-1 inhibits plasminogen activator inhibitor-1 (PAI-1) production by human articular cartilage and chondrocytesADAMTS-9 in Mouse Cartilage Has Aggrecanase Activity That Is Distinct from ADAMTS-4 and ADAMTS-5Degradation of cartilage aggrecan by collagenase-3 (MMP-13)Recombinant human aggrecan G1-G2 exhibits native binding properties and substrate specificity for matrix metalloproteinases and aggrecanaseAntibodies to MMP-cleaved aggrecanKeratan sulphate in the interglobular domain has a microstructure that is distinct from keratan sulphate elsewhere on pig aggrecan
P50
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P50
description
onderzoeker
@nl
researcher ORCID ID = 0000-0002-4396-8404
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name
Karena Last
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Karena Last
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Karena Last
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Karena Last
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Karena Last
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Karena Last
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Karena Last
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Karena Last
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Karena Last
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Karena Last
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Karena Last
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Karena Last
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P106
P1153
7003366202
P31
P496
0000-0002-4396-8404