Immunomodulation targeting abnormal protein conformation reduces pathology in a mouse model of Alzheimer's disease.
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Immunotherapeutic approaches for Alzheimer's diseaseMonoclonal antibodies against Aβ42 fibrils distinguish multiple aggregation state polymorphisms in vitro and in Alzheimer disease brain.Oligomer-targeting with a conformational antibody fragment promotes toxicity in Aβ-expressing flies.A vaccine with Aβ oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer's diseaseAmyloid β and Tau Alzheimer's disease related pathology is reduced by Toll-like receptor 9 stimulation.Novel immunological approaches for the treatment of Alzheimer's disease.Immunomodulation for prion and prion-related diseases.Development of a new DNA vaccine for Alzheimer disease targeting a wide range of aβ species and amyloidogenic peptidesBlocking the apolipoprotein E/amyloid-β interaction reduces fibrillar vascular amyloid deposition and cerebral microhemorrhages in TgSwDI mice.Induction of methionine-sulfoxide reductases protects neurons from amyloid β-protein insults in vitro and in vivo.Chemical Fluorescent Probe for Detection of Aβ Oligomers.Could immunomodulation be used to prevent prion diseases?Effects of an amyloid-beta 1-42 oligomers antibody screened from a phage display library in APP/PS1 transgenic mice.Active immunotherapy for Alzheimer's disease.Antibody-based therapy in Alzheimer's disease.Developing therapeutic vaccines against Alzheimer's disease.Production of Monoclonal Antibodies to Pathologic β-sheet Oligomeric Conformers in Neurodegenerative Diseases.Mucosal immunization with an attenuated Salmonella vaccine partially protects white-tailed deer from chronic wasting disease.Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice.Immunomodulation targeting of both Aβ and tau pathological conformers ameliorates Alzheimer's disease pathology in TgSwDI and 3xTg mouse models.Novel derivative of Paeonol, Paeononlsilatie sodium, alleviates behavioral damage and hippocampal dendritic injury in Alzheimer's disease concurrent with cofilin1/phosphorylated-cofilin1 and RAC1/CDC42 alterations in rats.Blocking the apolipoprotein E/amyloid β interaction in triple transgenic mice ameliorates Alzheimer's disease related amyloid β and tau pathology.The Peptide Vaccine Combined with Prior Immunization of a Conventional Diphtheria-Tetanus Toxoid Vaccine Induced Amyloid β Binding Antibodies on Cynomolgus Monkeys and Guinea Pigs.Nonhuman amyloid oligomer epitope reduces Alzheimer's-like neuropathology in 3xTg-AD transgenic mice.Self-Assembled Cyclic d,l-α-Peptides as Generic Conformational Inhibitors of the α-Synuclein Aggregation and Toxicity: In Vitro and Mechanistic Studies.Anti-β-sheet conformation monoclonal antibody reduces tau and Aβ oligomer pathology in an Alzheimer's disease model.Vaccines: chasing the dream.Immunotherapy to improve cognition and reduce pathological species in an Alzheimer's disease mouse model.
P2860
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P2860
Immunomodulation targeting abnormal protein conformation reduces pathology in a mouse model of Alzheimer's disease.
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Immunomodulation targeting abn ...... model of Alzheimer's disease.
@ast
Immunomodulation targeting abn ...... model of Alzheimer's disease.
@en
type
label
Immunomodulation targeting abn ...... model of Alzheimer's disease.
@ast
Immunomodulation targeting abn ...... model of Alzheimer's disease.
@en
prefLabel
Immunomodulation targeting abn ...... model of Alzheimer's disease.
@ast
Immunomodulation targeting abn ...... model of Alzheimer's disease.
@en
P2093
P2860
P50
P1433
P1476
Immunomodulation targeting abn ...... model of Alzheimer's disease.
@en
P2093
Feng-Xia Liang
Fernando Goñi
Frances Prelli
Henrieta Scholtzova
Pankaj Mehta
Regina Kascsak
Yanjie Sun
P2860
P304
P356
10.1371/JOURNAL.PONE.0013391
P407
P577
2010-10-13T00:00:00Z