Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699.
about
The role of PARP in DNA repair and its therapeutic exploitationPhase II study of irinotecan in combination with temozolomide (TEMIRI) in children with recurrent or refractory medulloblastoma: a joint ITCC and SIOPE brain tumor studyOvercoming multiple drug resistance mechanisms in medulloblastoma.Pediatric high-grade glioma: identification of poly(ADP-ribose) polymerase as a potential therapeutic target.Efficacy of PARP Inhibitor Rucaparib in Orthotopic Glioblastoma Xenografts Is Limited by Ineffective Drug Penetration into the Central Nervous System.Role of PARP inhibitors in cancer biology and therapyPARP1 Inhibitors: antitumor drug design.Molecular profiling of childhood cancer: Biomarkers and novel therapiesThe germline variants in DNA repair genes in pediatric medulloblastoma: a challenge for current therapeutic strategies.Synthetic lethality of PARP and NAMPT inhibition in triple-negative breast cancer cellsMismatch repair deficiency: a temozolomide resistance factor in medulloblastoma cell lines that is uncommon in primary medulloblastoma tumours.Therapeutic applications of PARP inhibitors: anticancer therapy and beyondDelineation of MGMT Hypermethylation as a Biomarker for Veliparib-Mediated Temozolomide-Sensitizing Therapy of GlioblastomaInhibiting the DNA damage response as a therapeutic manoeuvre in cancer.Preclinical evaluation of the PARP inhibitor, olaparib, in combination with cytotoxic chemotherapy in pediatric solid tumors.The rationale for targeted therapies in medulloblastoma.Tumour cell retention of rucaparib, sustained PARP inhibition and efficacy of weekly as well as daily schedulesTherapeutic intervention by the simultaneous inhibition of DNA repair and type I or type II DNA topoisomerases: one strategy, many outcomes.Poly(ADP-ribose) polymerase inhibitors in Ewing sarcoma.The potential of PARP inhibitors in neuro-oncology.PARP inhibitor attenuated colony formation can be restored by MAP kinase inhibitors in different irradiated cancer cell lines.Rucaparib: First Global Approval.PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation.Combined delivery of temozolomide and the thymidine kinase gene for treatment of glioblastoma.Sensitizing Ewing sarcoma to chemo- and radiotherapy by inhibition of the DNA-repair enzymes DNA protein kinase (DNA-PK) and poly-ADP-ribose polymerase (PARP) 1/2.
P2860
Q27002399-8F42BFE9-E033-4C88-9A48-738CDA2FA7CEQ33409117-B59F2D3E-956D-41C4-83BB-39F484B9DD69Q34500602-CA7077EF-61E5-44D5-A016-91D04B5CF155Q35568495-6942800D-8B2F-40F5-807E-BA3D0EDCD6B4Q35799917-4A0CB7C1-2AB0-47B6-8970-5EA05F137209Q36171193-F862AB8F-95F6-4995-B717-9682F93D2606Q36175159-3F7F2655-7608-4AEF-973B-A375ADC6AB02Q36250783-C1E0BA09-FB31-48E6-8D10-79D7D5089094Q36334648-5F132D7B-71BF-4A91-9A08-9A38FBC02F17Q36379543-B72DD1BD-97CC-4DAF-A801-686516307797Q36387895-FCF8CD9F-16C0-466B-907A-B57CF9AFC0B9Q36853236-55ED8D17-2B81-4FCF-A520-3B5C38302388Q36887663-F0CF84EC-5212-434E-8979-1450B7BA7123Q37122690-151ACFCA-E640-4D8F-BD7C-373C8A99FD21Q37362118-327E0735-DD81-4C03-860C-20ECC3EC5E95Q37409736-79520B39-B67A-47F6-A08E-17A51E5D20B4Q37711694-94D7DFB7-762E-444A-A275-C258EE85FA13Q37968253-63024496-0DFA-444E-9051-553B582C1B2EQ38212771-157CA7C9-99E1-46B6-901E-66AFC6DFEA71Q38233068-D2EA689B-AB2A-4C58-A0EA-212AEBA40C91Q38983905-5AD3B941-0362-4254-A846-57BEB07A3605Q39155735-FEC38728-59A9-42DF-A431-7E40890CE7B9Q39425287-60353B1C-40A5-4D29-BD9A-0760FBD643B5Q40657080-B1DC4EB0-898E-46D4-A25B-09D9C341866AQ47710977-611922FE-936A-4160-81B2-385BAED13DB8
P2860
Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699.
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Central nervous system penetra ...... olymerase inhibitor AG-014699.
@ast
Central nervous system penetra ...... olymerase inhibitor AG-014699.
@en
type
label
Central nervous system penetra ...... olymerase inhibitor AG-014699.
@ast
Central nervous system penetra ...... olymerase inhibitor AG-014699.
@en
prefLabel
Central nervous system penetra ...... olymerase inhibitor AG-014699.
@ast
Central nervous system penetra ...... olymerase inhibitor AG-014699.
@en
P2093
P2860
P356
P1476
Central nervous system penetra ...... polymerase inhibitor AG-014699
@en
P2093
A L Rozanska
D A Tweddle
D J Castelbuono
E A Mulligan
E R Plummer
H D Thomas
R A Daniel
S C Clifford
Z Hostomsky
P2860
P2888
P304
P356
10.1038/SJ.BJC.6605946
P407
P577
2010-10-26T00:00:00Z
P5875
P6179
1041433639