Apurinic/apyrimidinic endonuclease APE1 is required for PACAP-induced neuroprotection against global cerebral ischemia. - Wikidata - awgldk - TriplyDB

Apurinic/apyrimidinic endonuclease APE1 is required for PACAP-induced neuroprotection against global cerebral ischemia.

Apurinic/apyrimidinic endonuclease APE1 is required for PACAP-induced neuroprotection against global cerebral ischemia.

http://www.wikidata.org/entity/Q33733611

about

The excitatory neurotransmitter glutamate stimulates DNA repair to increase neuronal resiliency Microglia-Induced Maladaptive Plasticity Can Be Modulated by Neuropeptides In Vivo Protective effects and mechanisms of sirtuins in the nervous system PACAP deficiency sensitizes nigrostriatal dopaminergic neurons to paraquat-induced damage and modulates central and peripheral inflammatory activation in mice Proteomic study of amyloid beta (25-35) peptide exposure to neuronal cells: Impact on APE1/Ref-1's protein-protein interaction Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease APE1/Ref-1 as an emerging therapeutic target for various human diseases: phytochemical modulation of its functions Neuroprotective roles of pituitary adenylate cyclase-activating polypeptide in neurodegenerative diseases.Scriptaid, a novel histone deacetylase inhibitor, protects against traumatic brain injury via modulation of PTEN and AKT pathway : scriptaid protects against TBI via AKT.Posttranslational modification of mammalian AP endonuclease (APE1).Mechanistic insight into DNA damage and repair in ischemic stroke: exploiting the base excision repair pathway as a model of neuroprotection.Identification and quantification of DNA repair protein apurinic/apyrimidinic endonuclease 1 (APE1) in human cells by liquid chromatography/isotope-dilution tandem mass spectrometry.Cyclic AMP is both a pro-apoptotic and anti-apoptotic second messenger STC1 induction by PACAP is mediated through cAMP and ERK1/2 but not PKA in cultured cortical neurons Transgenic overexpression of peroxiredoxin-2 attenuates ischemic neuronal injury via suppression of a redox-sensitive pro-death signaling pathway Nuclear depletion of apurinic/apyrimidinic endonuclease 1 (Ape1/Ref-1) is an indicator of energy disruption in neurons Base excision repair in physiology and pathology of the central nervous system Mitochondrial biogenesis contributes to ischemic neuroprotection afforded by LPS pre-conditioning.VIP and PACAP: neuropeptide modulators of CNS inflammation, injury, and repair APE1/Ref-1 facilitates recovery of gray and white matter and neurological function after mild stroke injury.17β-estradiol increases expression of the oxidative stress response and DNA repair protein apurinic endonuclease (Ape1) in the cerebral cortex of female mice following hypoxia.Base excision repair in the mammalian brain: implication for age related neurodegeneration Human apurinic/apyrimidinic endonuclease 1.BDNF and exercise enhance neuronal DNA repair by stimulating CREB-mediated production of apurinic/apyrimidinic endonuclease 1.The prion protein is critical for DNA repair and cell survival after genotoxic stress.PACAP Protects the Adolescent and Adult Mice Brain from Ethanol Toxicity and Modulates Distinct Sets of Genes Regulating Similar Networks.Toll-like receptor 4 signaling is involved in PACAP-induced neuroprotection in BV2 microglial cells under OGD/reoxygenation.Involvement of endogenous antioxidant systems in the protective activity of pituitary adenylate cyclase-activating polypeptide against hydrogen peroxide-induced oxidative damages in cultured rat astrocytes.Activation of GLP-1 Receptor Enhances Neuronal Base Excision Repair via PI3K-AKT-Induced Expression of Apurinic/Apyrimidinic Endonuclease 1 The Emerging Role of GLP-1 Receptors in DNA Repair: Implications in Neurological Disorders.Pituitary adenylate cyclase-activating polypeptide (PACAP) inhibits the slow afterhyperpolarizing current sIAHP in CA1 pyramidal neurons by activating multiple signaling pathways.Apurinic/apyrimidinic endonuclease 1 upregulation reduces oxidative DNA damage and protects hippocampal neurons from ischemic injury.Development of a Cell-Based Assay for Measuring Base Excision Repair Responses.Apoptosis-Resistant Cardiac Progenitor Cells Modified With Apurinic/Apyrimidinic Endonuclease/Redox Factor 1 Gene Overexpression Regulate Cardiac Repair After Myocardial Infarction.Protective effects of PACAP in ischemia.Unilateral ureteral obstruction induces DNA repair by APE1.

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Apurinic/apyrimidinic endonuclease APE1 is required for PACAP-induced neuroprotection against global cerebral ischemia.

http://www.wikidata.org/entity/Q33733611

description

2010 nî lūn-bûn

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2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի փետրվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Apurinic/apyrimidinic endonucl ...... inst global cerebral ischemia.

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Apurinic/apyrimidinic endonucl ...... inst global cerebral ischemia.

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Apurinic/apyrimidinic endonucl ...... inst global cerebral ischemia.

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Apurinic/apyrimidinic endonucl ...... inst global cerebral ischemia.

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Apurinic/apyrimidinic endonucl ...... inst global cerebral ischemia.

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Apurinic/apyrimidinic endonucl ...... inst global cerebral ischemia.

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Proceedings of the National Academy of Sciences of the United States of America

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Apurinic/apyrimidinic endonucl ...... inst global cerebral ischemia.

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Feng Zhang

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Guodong Cao

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Jun Chen

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Lili Zhang

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Michael V L Bennett

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Peter S Vosler

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R Anne Stetler

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R Suzanne Zukin

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Yanqin Gao

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P2860

Endogenous DNA abasic sites cause cell death in the absence of Apn1, Apn2 and Rad1/Rad10 in Saccharomyces cerevisiae.

The intracellular localization of APE1/Ref-1: more than a passive phenomenon?

Somatic and axonal effects of ATP via P2X2 but not P2X7 receptors in rat thoracolumbar sympathetic neurones.

Ischemic insults promote epigenetic reprogramming of mu opioid receptor expression in hippocampal neurons.

Role of PACAP in ischemic neural death.

DNA damage by oxygen-derived species. Its mechanism and measurement in mammalian systems.

Pituitary adenylate cyclase-activating polypeptide (PACAP) alters parasympathetic neuron gene expression in a time-dependent fashion.

Dual blockade of cyclic AMP response element- (CRE) and AP-1-directed transcription by CRE-transcription factor decoy oligonucleotide. gene-specific inhibition of tumor growth.

A dominant-negative form of the major human abasic endonuclease enhances cellular sensitivity to laboratory and clinical DNA-damaging agents.

Genotoxic lipid peroxidation products: their DNA damaging properties and role in formation of endogenous DNA adducts.

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3204-3209

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7

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20133634

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cerebral infarction

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