A dominant-negative form of the major human abasic endonuclease enhances cellular sensitivity to laboratory and clinical DNA-damaging agents.
about
Human AP endonuclease 1: a potential marker for the prediction of environmental carcinogenesis riskOverview of base excision repair biochemistryIdentification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1Diverse small molecule inhibitors of human apurinic/apyrimidinic endonuclease APE1 identified from a screen of a large public collectionSirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restrictionMetallofullerene nanoparticles circumvent tumor resistance to cisplatin by reactivating endocytosis.Immunohistochemical analysis of oxidative stress and DNA repair proteins in normal mammary and breast cancer tissues.Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells.The many functions of APE1/Ref-1: not only a DNA repair enzymeApurinic/apyrimidinic endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge.Apurinic/apyrimidinic endonuclease APE1 is required for PACAP-induced neuroprotection against global cerebral ischemia.Redox regulation of DNA repair: implications for human health and cancer therapeutic development.Suppression of choroidal neovascularization through inhibition of APE1/Ref-1 redox activity.Small molecule inhibitors of DNA repair nuclease activities of APE1.Killing effect of Ad5/F35-APE1 siRNA recombinant adenovirus in combination with hematoporphrphyrin derivative-mediated photodynamic therapy on human nonsmall cell lung cancerTip60 is regulated by circadian transcription factor clock and is involved in cisplatin resistance.Specific inhibition of the redox activity of ape1/ref-1 by e3330 blocks tnf-α-induced activation of IL-8 production in liver cancer cell linesThe repair function of the multifunctional DNA repair/redox protein APE1 is neuroprotective after ionizing radiation.Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growthKnock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and functionAPE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1.Base excision repair: contribution to tumorigenesis and target in anticancer treatment paradigmsCapturing snapshots of APE1 processing DNA damage.Knockdown of the DNA repair and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell and tumor growthInhibition of DNA-repair genes Ercc1 and Mgmt enhances temozolomide efficacy in gliomas treatment: a pre-clinical study.5-Fluorouracil mediated anti-cancer activity in colon cancer cells is through the induction of Adenomatous Polyposis Coli: Implication of the long-patch base excision repair pathway.Evidence for base excision repair processing of DNA interstrand crosslinks.Characterization of Mg2+ binding to the DNA repair protein apurinic/apyrimidic endonuclease 1 via solid-state 25Mg NMR spectroscopy.Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors.Participation of DNA repair in the response to 5-fluorouracil.Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells.Going ape as an approach to cancer therapeutics.Potent inhibition of human apurinic/apyrimidinic endonuclease 1 by arylstibonic acids.Impairment of APE1 function enhances cellular sensitivity to clinically relevant alkylators and antimetabolites.Embryonic stem cells lacking the epigenetic regulator Cfp1 are hypersensitive to DNA-damaging agents and exhibit decreased Ape1/Ref-1 protein expression and endonuclease activity.Human apurinic/apyrimidinic endonuclease 1.Elevated level of acetylation of APE1 in tumor cells modulates DNA damage repair.Small-molecule inhibitors of DNA damage-repair pathways: an approach to overcome tumor resistance to alkylating anticancer drugs.Tumor-associated APE1 variant exhibits reduced complementation efficiency but does not promote cancer cell phenotypes.
P2860
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P2860
A dominant-negative form of the major human abasic endonuclease enhances cellular sensitivity to laboratory and clinical DNA-damaging agents.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
A dominant-negative form of th ...... clinical DNA-damaging agents.
@en
type
label
A dominant-negative form of th ...... clinical DNA-damaging agents.
@en
prefLabel
A dominant-negative form of th ...... clinical DNA-damaging agents.
@en
P1476
A dominant-negative form of th ...... clinical DNA-damaging agents.
@en
P2093
Daniel R McNeill
David M Wilson
P356
10.1158/1541-7786.MCR-06-0329
P577
2007-01-01T00:00:00Z