A role for copper in the toxicity of zinc-deficient superoxide dismutase to motor neurons in amyotrophic lateral sclerosis
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Tempol moderately extends survival in a hSOD1(G93A) ALS rat model by inhibiting neuronal cell loss, oxidative damage and levels of non-native hSOD1(G93A) formsInhibitory synaptic regulation of motoneurons: a new target of disease mechanisms in amyotrophic lateral sclerosis.Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SOD(G93A) mice co-expressing the Copper-Chaperone-for-SODParadoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health ImplicationsClinical perspective on oxidative stress in sporadic amyotrophic lateral sclerosisParsing Disease-relevant Protein Modifications from Epiphenomena: Perspective on the Structural Basis of SOD1-Mediated ALS.Blood levels of trace metals and amyotrophic lateral sclerosisMitochondrial pathobiology in ALS.Expression of zinc-deficient human superoxide dismutase in Drosophila neurons produces a locomotor defect linked to mitochondrial dysfunction.Nitric oxide-mediated oxidative damage and the progressive demise of motor neurons in ALS.Copper and zinc metallation status of copper-zinc superoxide dismutase from amyotrophic lateral sclerosis transgenic mice.Cupric ions induce the oxidation and trigger the aggregation of human superoxide dismutase 1The carbonylation and covalent dimerization of human superoxide dismutase 1 caused by its bicarbonate-dependent peroxidase activity is inhibited by the radical scavenger tempol.Biochemical properties and in vivo effects of the SOD1 zinc-binding site mutant (H80G)Metal-deficient SOD1 in amyotrophic lateral sclerosis.Dietary Vitamin D3 Restriction Exacerbates Disease Pathophysiology in the Spinal Cord of the G93A Mouse Model of Amyotrophic Lateral SclerosisThe microscopic and ultramicroscopic changes in the skeletal muscles, caused by heavy metal saltsBiology of mitochondria in neurodegenerative diseases.The right to choose: multiple pathways for activating copper,zinc superoxide dismutase.SOD1 and TDP-43 animal models of amyotrophic lateral sclerosis: recent advances in understanding disease toward the development of clinical treatments.Characterization of biometal profiles in neurological disorders.Nitric oxide inactivation mechanisms in the brain: role in bioenergetics and neurodegeneration.Oxidation of the tryptophan 32 residue of human superoxide dismutase 1 caused by its bicarbonate-dependent peroxidase activity triggers the non-amyloid aggregation of the enzymeCytosolic superoxide dismutase (SOD1) is critical for tolerating the oxidative stress of zinc deficiency in yeast.Impaired Cu-Zn Superoxide Dismutase (SOD1) and Calcineurin (Cn) Interaction in ALS: A Presumed Consequence for TDP-43 and Zinc Aggregation in Tg SOD1G93A Rodent Spinal Cord Tissue.Molecular dynamics of a far positioned SOD1 mutant V14M reveals pathogenic misfolding behavior.A Cystine-Rich Whey Supplement (Immunocal®) Provides Neuroprotection from Diverse Oxidative Stress-Inducing Agents In Vitro by Preserving Cellular Glutathione.Study of mutation and misfolding of Cu-Zn SOD1 protein.Cholesterol secosterol aldehyde adduction and aggregation of Cu,Zn-superoxide dismutase: Potential implications in ALS
P2860
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P2860
A role for copper in the toxicity of zinc-deficient superoxide dismutase to motor neurons in amyotrophic lateral sclerosis
description
2009 nî lūn-bûn
@nan
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
A role for copper in the toxic ...... amyotrophic lateral sclerosis
@ast
A role for copper in the toxic ...... amyotrophic lateral sclerosis
@en
type
label
A role for copper in the toxic ...... amyotrophic lateral sclerosis
@ast
A role for copper in the toxic ...... amyotrophic lateral sclerosis
@en
prefLabel
A role for copper in the toxic ...... amyotrophic lateral sclerosis
@ast
A role for copper in the toxic ...... amyotrophic lateral sclerosis
@en
P2860
P356
P1476
A role for copper in the toxic ...... amyotrophic lateral sclerosis
@en
P2093
Joseph S Beckman
Kari A Trumbull
P2860
P304
P356
10.1089/ARS.2009.2574
P577
2009-07-01T00:00:00Z