Single mutations change CYP2F3 from a dehydrogenase of 3-methylindole to an oxygenase. - Wikidata - awgldk - TriplyDB

Single mutations change CYP2F3 from a dehydrogenase of 3-methylindole to an oxygenase.

Single mutations change CYP2F3 from a dehydrogenase of 3-methylindole to an oxygenase.

http://www.wikidata.org/entity/Q33745413

about

Improved cytochrome P450 3A4 molecular models accurately predict the Phe215 requirement for raloxifene dehydrogenation selectivity.Potent mutagenicity of 3-methylindole requires pulmonary cytochrome P450-mediated bioactivation: a comparison to the prototype cigarette smoke mutagens B(a)P and NNK.Directed evolution reveals requisite sequence elements in the functional expression of P450 2F1 in Escherichia coli Intramolecular gas-phase reactions of synthetic nonheme oxoiron(IV) ions: proximity and spin-state reactivity rules Shape-selective interception by hydrocarbons of the O2-derived oxidant of a biomimetic nonheme iron complex.3-Methylindole is mutagenic and a possible pulmonary carcinogen Directed evolution of cytochrome P450 enzymes for biocatalysis: exploiting the catalytic versatility of enzymes with relaxed substrate specificity.

P2860

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P2860

Single mutations change CYP2F3 from a dehydrogenase of 3-methylindole to an oxygenase.

http://www.wikidata.org/entity/Q33745413

description

2008 nî lūn-bûn

@nan

2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

name

Single mutations change CYP2F3 from a dehydrogenase of 3-methylindole to an oxygenase.

@ast

Single mutations change CYP2F3 from a dehydrogenase of 3-methylindole to an oxygenase.

@en

type

label

Single mutations change CYP2F3 from a dehydrogenase of 3-methylindole to an oxygenase.

@ast

Single mutations change CYP2F3 from a dehydrogenase of 3-methylindole to an oxygenase.

@en

prefLabel

Single mutations change CYP2F3 from a dehydrogenase of 3-methylindole to an oxygenase.

@ast

Single mutations change CYP2F3 from a dehydrogenase of 3-methylindole to an oxygenase.

@en

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Single mutations change CYP2F3 from a dehydrogenase of 3-methylindole to an oxygenase.

@en

P2093

Christopher A Reilly

http://www.w3.org/2001/XMLSchema#string

Clifton Hall

http://www.w3.org/2001/XMLSchema#string

Eric F Johnson

http://www.w3.org/2001/XMLSchema#string

Garold S Yost

http://www.w3.org/2001/XMLSchema#string

Hao Sun

http://www.w3.org/2001/XMLSchema#string

Jaya S Kartha

http://www.w3.org/2001/XMLSchema#string

Konstantine W Skordos

http://www.w3.org/2001/XMLSchema#string

LaHoma M Easterwood

http://www.w3.org/2001/XMLSchema#string

P2860

Specific dehydrogenation of 3-methylindole and epoxidation of naphthalene by recombinant human CYP2F1 expressed in lymphoblastoid cells

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Crystal structure of human cytochrome P450 2C9 with bound warfarin

Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site

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Key substrate recognition residues in the active site of a plant cytochrome P450, CYP73A1. Homology guided site-directed mutagenesis.

Involvement of CYP2E1 and carboxylesterase enzymes in vinyl carbamate metabolism in human lung microsomes.

Uncommon P450-catalyzed reactions.

The use of deuterium isotope effects to probe the active site properties, mechanism of cytochrome P450-catalyzed reactions, and mechanisms of metabolically dependent toxicity.

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scholarly article

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10.1021/BI8005658

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37

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47

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18717595

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