Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site - Wikidata - awgldk - TriplyDB

Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site

Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site

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Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2 Crystal structure of human cytochrome P450 2D6 Structural characterization of human cytochrome P450 2C19: active site differences between P450s 2C8, 2C9, and 2C19 Structural characterization of the complex between alpha-naphthoflavone and human cytochrome P450 1B1 Membrane position of ibuprofen agrees with suggested access path entrance to cytochrome P450 2C9 active site The discovery of new coding alleles of human CYP26A1 that are potentially defective in the metabolism of all-trans retinoic acid and their assessment in a recombinant cDNA expression system Structural diversity of eukaryotic membrane cytochrome p450s Structural insight into the altered substrate specificity of human cytochrome P450 2A6 mutants Determinants of Cytochrome P450 2C8 Substrate Binding: STRUCTURES OF COMPLEXES WITH MONTELUKAST, TROGLITAZONE, FELODIPINE, AND 9-CIS-RETINOIC ACID Modes of heme binding and substrate access for cytochrome P450 CYP74A revealed by crystal structures of allene oxide synthase Crystal Structures of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-methyl-1 H -imidazole: Ligand-Induced Structural Response through α-Helical Repositioning ,Crystal Structure of Human Cytochrome P450 2D6 with Prinomastat Bound Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer Structural evidence: a single charged residue affects substrate binding in cytochrome P450 BM-3 Prediction of protein orientation upon immobilization on biological and nonbiological surfaces Homology model of human retinoic acid metabolising enzyme cytochrome P450 26A1 (CYP26A1): active site architecture and ligand binding Examination of 209 drugs for inhibition of cytochrome P450 2C8 Variations on a (t)heme--novel mechanisms, redox partners and catalytic functions in the cytochrome P450 superfamily Structure and dynamics of the membrane-bound cytochrome P450 2C9 Identifying cytochrome p450 functional networks and their allosteric regulatory elements A multiscale approach to modelling drug metabolism by membrane-bound cytochrome P450 enzymes Automated protein structure homology modeling: a progress report.Structural features of cytochromes P450 and ligands that affect drug metabolism as revealed by X-ray crystallography and NMR.Peripheral ligand-binding site in cytochrome P450 3A4 located with fluorescence resonance energy transfer (FRET)Expansion of substrate specificity of cytochrome P450 2A6 by random and site-directed mutagenesis.Allosteric transitions in cytochrome P450eryF explored with pressure-perturbation spectroscopy, lifetime FRET, and a novel fluorescent substrate, Fluorol-7GA.Structural and functional insights into polymorphic enzymes of cytochrome P450 2C8.Single mutations change CYP2F3 from a dehydrogenase of 3-methylindole to an oxygenase.The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0-A resolution.Homology modeling of mosquito cytochrome P450 enzymes involved in pyrethroid metabolism: insights into differences in substrate selectivity.Computational and in vitro studies on the inhibitory effects of herbal compounds on human cytochrome P450 1A2.CYP2C8 exists as a dimer in natural membranes.Renal drug metabolism in humans: the potential for drug-endobiotic interactions involving cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT).Resolution of two substrate-binding sites in an engineered cytochrome P450eryF bearing a fluorescent probe.Do mammalian cytochrome P450s show multiple ligand access pathways and ligand channelling?Cerivastatin in vitro metabolism by CYP2C8 variants found in patients experiencing rhabdomyolysis Participation of CYP2C8 and CYP3A4 in the N-demethylation of imatinib in human hepatic microsomes.Targeting of splice variants of human cytochrome P450 2C8 (CYP2C8) to mitochondria and their role in arachidonic acid metabolism and respiratory dysfunction.Defining the primary route for lutein synthesis in plants: the role of Arabidopsis carotenoid beta-ring hydroxylase CYP97A3

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Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site

http://www.wikidata.org/entity/Q27642793

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2004 nî lūn-bûn

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2004 թուականի Մարտին հրատարակուած գիտական յօդուած

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2004 թվականի մարտին հրատարակված գիտական հոդված

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2004年の論文

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Structure of human microsomal ...... pheral fatty acid binding site

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Structure of human microsomal ...... pheral fatty acid binding site

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Structure of human microsomal ...... pheral fatty acid binding site

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Journal of Biological Chemistry

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Structure of human microsomal ...... pheral fatty acid binding site

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C David Stout

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Eric F Johnson

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Guillaume A Schoch

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Jason K Yano

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Keith J Griffin

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Michael R Wester

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Initial sequencing and comparative analysis of the mouse genome

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

PROCHECK: a program to check the stereochemical quality of protein structures

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity

Crystal structure of a thermophilic cytochrome P450 from the archaeon Sulfolobus solfataricus

Substrate recognition and molecular mechanism of fatty acid hydroxylation by cytochrome P450 from Bacillus subtilis. Crystallographic, spectroscopic, and mutational studies

Structure of a substrate complex of mammalian cytochrome P450 2C5 at 2.3 A resolution: evidence for multiple substrate binding modes

Structure of mammalian cytochrome P450 2C5 complexed with diclofenac at 2.1 A resolution: evidence for an induced fit model of substrate binding

An open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolution

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10.1074/JBC.M312516200

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10

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279

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14676196

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