B cell-specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia. - Wikidata - awgldk - TriplyDB

B cell-specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia.

B cell-specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia.

http://www.wikidata.org/entity/Q33747337

about

Advances of gene therapy for primary immunodeficiencies Gene therapy for primary immunodeficiencies Current translational and clinical practices in hematopoietic cell and gene therapy Daedalus: a robust, turnkey platform for rapid production of decigram quantities of active recombinant proteins in human cell lines using novel lentiviral vectors Development of B-lineage predominant lentiviral vectors for use in genetic therapies for B cell disorders Progressive engineering of a homing endonuclease genome editing reagent for the murine X-linked immunodeficiency locus.Successful targeting and disruption of an integrated reporter lentivirus using the engineered homing endonuclease Y2 I-AniI.Gene transfer into hematopoietic stem cells as treatment for primary immunodeficiency diseases.Intraosseous delivery of lentiviral vectors targeting factor VIII expression in platelets corrects murine hemophilia A.Generation of a lentiviral vector producer cell clone for human Wiskott-Aldrich syndrome gene therapy.Ubiquitous high-level gene expression in hematopoietic lineages provides effective lentiviral gene therapy of murine Wiskott-Aldrich syndrome.Altered B cell homeostasis is associated with type I diabetes and carriers of the PTPN22 allelic variant.A genome editing primer for the hematologist Genotoxicity of retroviral hematopoietic stem cell gene therapy.New frontiers of primary antibody deficiencies.Primary antibody deficiencies.Agammaglobulinemia: causative mutations and their implications for novel therapies.Gene therapy for primary immunodeficiencies.Safe and Effective Gene Therapy for Murine Wiskott-Aldrich Syndrome Using an Insulated Lentiviral Vector Single cell imaging of Bruton's tyrosine kinase using an irreversible inhibitor.Gene delivery in malignant B cells using the combination of lentiviruses conjugated to anti-transferrin receptor antibodies and an immunoglobulin promoter.Evolving Gene Therapy in Primary Immunodeficiency.Targeting expression to megakaryocytes and platelets by lineage-specific lentiviral vectors.Bruton's tyrosine kinase: from X-linked agammaglobulinemia toward targeted therapy for B-cell malignancies.Developmentally regulated expression of MEF2C limits the response to BCR engagement in transitional B cells Successful hematopoietic cell transplantation in a patient with X-linked agammaglobulinemia and acute myeloid leukemia.Biology and novel treatment options for XLA, the most common monogenetic immunodeficiency in man.IgM Augments Complement Bactericidal Activity with Serum from a Patient with a Novel CD79a Mutation.

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P2860

B cell-specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia.

http://www.wikidata.org/entity/Q33747337

description

2010 nî lūn-bûn

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2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

B cell-specific lentiviral gen ...... f X-linked agammaglobulinemia.

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B cell-specific lentiviral gen ...... f X-linked agammaglobulinemia.

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type

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B cell-specific lentiviral gen ...... f X-linked agammaglobulinemia.

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B cell-specific lentiviral gen ...... f X-linked agammaglobulinemia.

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B cell-specific lentiviral gen ...... f X-linked agammaglobulinemia.

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B cell-specific lentiviral gen ...... f X-linked agammaglobulinemia.

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B cell-specific lentiviral gen ...... f X-linked agammaglobulinemia.

@en

P2093

Alexander Astrakhan

http://www.w3.org/2001/XMLSchema#string

Blythe D Sather

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Brigid V Stirling

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Byoung Y Ryu

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David J Rawlings

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Denny Liggitt

http://www.w3.org/2001/XMLSchema#string

Hannah M Kerns

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Stephanie Humblet-Baron

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P2860

Gene therapy for severe combined immunodeficiency: are we there yet?

A third-generation lentivirus vector with a conditional packaging system

Transcription start regions in the human genome are favored targets for MLV integration

HIV-1 integration in the human genome favors active genes and local hotspots

Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia.

A novel mutation (Cys145-->Stop) in Bruton's tyrosine kinase is associated with newly diagnosed X-linked agammaglobulinemia in a 51-year-old male.

Adults with X-linked agammaglobulinemia: impact of disease on daily lives, quality of life, educational and socioeconomic status, knowledge of inheritance, and reproductive attitudes.

Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors.

Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation.

Deficiency of Bruton's tyrosine kinase in B cell precursor leukemia cells.

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2146-2155

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scholarly article

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10.1182/BLOOD-2009-09-241869

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11

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115

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2010-01-21T00:00:00Z

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41111515

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20093406

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2844021

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