Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors. - Wikidata - awgldk - TriplyDB

Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors.

Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors.

http://www.wikidata.org/entity/Q33713156

about

Lentiviral vectors in gene therapy: their current status and future potential A transposon and transposase system for human application Clinical development of gene therapy: results and lessons from recent successes The utility of transposon mutagenesis for cancer studies in the era of genome editing.Hematopoietic stem cell engineering at a crossroads Gene therapy on the move Hematopoietic-stem-cell-based gene therapy for HIV disease An advanced preclinical mouse model for acute myeloid leukemia using patients' cells of various genetic subgroups and in vivo bioluminescence imaging Identifying Cancer Driver Genes Using Replication-Incompetent Retroviral Vectors Uncovering and dissecting the genotoxicity of self-inactivating lentiviral vectors in vivo Generation of healthy mice from gene-corrected disease-specific induced pluripotent stem cells Gene Therapy for X-Linked Severe Combined Immunodeficiency: Where Do We Stand?Development of B-lineage predominant lentiviral vectors for use in genetic therapies for B cell disorders Hematopoietic stem cell and gene therapy corrects primary neuropathology and behavior in mucopolysaccharidosis IIIA mice.Dynamic clonal analysis of murine hematopoietic stem and progenitor cells marked by 5 fluorescent proteins using confocal and multiphoton microscopy.Gene therapy model of X-linked severe combined immunodeficiency using a modified foamy virus vector Preclinical safety and efficacy of human CD34(+) cells transduced with lentiviral vector for the treatment of Wiskott-Aldrich syndrome.Wiskott-Aldrich syndrome: a comprehensive review.Comparison of insulators and promoters for expression of the Wiskott-Aldrich syndrome protein using lentiviral vectors.A genome-integrated massively parallel reporter assay reveals DNA sequence determinants of cis-regulatory activity in neural cells Long-term tracking of segmental bone healing mediated by genetically engineered adipose-derived stem cells: focuses on bone remodeling and potential side effects.B cell-specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia.Lentiviral and targeted cellular barcoding reveals ongoing clonal dynamics of cell lines in vitro and in vivo Genome-wide analysis of alpharetroviral integration in human hematopoietic stem/progenitor cells.Integration-specific In Vitro Evaluation of Lentivirally Transduced Rhesus CD34(+) Cells Correlates With In Vivo Vector Copy Number.Curing genetic disease with gene therapy.Use of the piggyBac transposon to create stable packaging cell lines for the production of clinical-grade self-inactivating γ-retroviral vectors.Translating Sleeping Beauty transposition into cellular therapies: victories and challenges.Lineage- and stage-restricted lentiviral vectors for the gene therapy of chronic granulomatous disease.Scavenger receptors and their potential as therapeutic targets in the treatment of cardiovascular disease Erythroid promoter confines FGF2 expression to the marrow after hematopoietic stem cell gene therapy and leads to enhanced endosteal bone formation.Human cardiac progenitor cells engineered with Pim-I kinase enhance myocardial repair.Thymidine kinase suicide gene-mediated ganciclovir ablation of autologous gene-modified rhesus hematopoiesis.Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome.Preclinical evaluation of efficacy and safety of an improved lentiviral vector for the treatment of β-thalassemia and sickle cell disease.Biochemical correction of X-CGD by a novel chimeric promoter regulating high levels of transgene expression in myeloid cells.Gene therapy of chronic granulomatous disease: the engraftment dilemma Understanding lentiviral vector chromatin targeting: working to reduce insertional mutagenic potential for gene therapy.Safe engineering of CAR T cells for adoptive cell therapy of cancer using long-term episomal gene transfer.Deletion of the LTR enhancer/promoter has no impact on the integration profile of MLV vectors in human hematopoietic progenitors.

P2860

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P2860

Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors.

http://www.wikidata.org/entity/Q33713156

description

2009 nî lūn-bûn

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2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի օգոստոսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Insertional transformation of ...... l and gammaretroviral vectors.

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Insertional transformation of ...... l and gammaretroviral vectors.

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Insertional transformation of ...... l and gammaretroviral vectors.

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Insertional transformation of ...... l and gammaretroviral vectors.

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Molecular Therapy

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Insertional transformation of ...... l and gammaretroviral vectors.

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Anne Galy

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Christopher Baum

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Daniela Zychlinski

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Juan Bueren

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Sabine Charrier

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Sabine Knoess

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Susana Navarro

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Tobias Maetzig

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Ute Modlich

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P2860

Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics

EVI1 and hematopoietic disorders: history and perspectives

Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

Hot spots of retroviral integration in human CD34+ hematopoietic cells

Transcription start regions in the human genome are favored targets for MLV integration

Retroviral DNA integration: viral and cellular determinants of target-site selection

Evidence for long-term efficacy and safety of gene therapy for Wiskott-Aldrich syndrome in preclinical models.

Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors.

Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.

Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways.

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1919-1928

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scholarly article

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10.1038/MT.2009.179

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11

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17

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Daniela Zychlinski

Martijn Brugman

Adrian J Thrasher

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2009-08-11T00:00:00Z

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26733750

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19672245

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2835038

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