Development of a quantitative RT-PCR assay to examine the kinetics of ribosome depurination by ribosome inactivating proteins using Saccharomyces cerevisiae as a model.
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Do the A subunits contribute to the differences in the toxicity of Shiga toxin 1 and Shiga toxin 2?The A1 Subunit of Shiga Toxin 2 Has Higher Affinity for Ribosomes and Higher Catalytic Activity than the A1 Subunit of Shiga Toxin 1.Generality of toxins in defensive symbiosis: Ribosome-inactivating proteins and defense against parasitic wasps in Drosophila.Functional divergence between the two P1-P2 stalk dimers on the ribosome in their interaction with ricin A chainA ribosome-inactivating protein in a Drosophila defensive symbiont.Passive and active vaccination strategies to prevent ricin poisoning.Wild type RTA and less toxic variants have distinct requirements for Png1 for their depurination activity and toxicity in Saccharomyces cerevisiaeShiga toxin 1 is more dependent on the P proteins of the ribosomal stalk for depurination activity than Shiga toxin 2Ricinus communis intoxications in human and veterinary medicine-a summary of real cases.The P1/P2 proteins of the human ribosomal stalk are required for ribosome binding and depurination by ricin in human cellsN-glycosylation does not affect the catalytic activity of ricin a chain but stimulates cytotoxicity by promoting its transport out of the endoplasmic reticulum.Arginine residues on the opposite side of the active site stimulate the catalysis of ribosome depurination by ricin A chain by interacting with the P-protein stalkConserved Arginines at the P-Protein Stalk Binding Site and the Active Site Are Critical for Ribosome Interactions of Shiga Toxins but Do Not Contribute to Differences in the Affinity of the A1 Subunits for the Ribosome.Ricin uses arginine 235 as an anchor residue to bind to P-proteins of the ribosomal stalk.Functional Assays for Measuring the Catalytic Activity of Ribosome Inactivating Proteins.Peptide Mimics of the Ribosomal P Stalk Inhibit the Activity of Ricin A Chain by Preventing Ribosome Binding
P2860
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P2860
Development of a quantitative RT-PCR assay to examine the kinetics of ribosome depurination by ribosome inactivating proteins using Saccharomyces cerevisiae as a model.
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Development of a quantitative ...... romyces cerevisiae as a model.
@ast
Development of a quantitative ...... romyces cerevisiae as a model.
@en
type
label
Development of a quantitative ...... romyces cerevisiae as a model.
@ast
Development of a quantitative ...... romyces cerevisiae as a model.
@en
prefLabel
Development of a quantitative ...... romyces cerevisiae as a model.
@ast
Development of a quantitative ...... romyces cerevisiae as a model.
@en
P2093
P2860
P356
P1433
P1476
Development of a quantitative ...... romyces cerevisiae as a model.
@en
P2093
Jennifer Nielsen Kahn
Jiachi Chiou
Michael Pierce
Nilgun E Tumer
P2860
P304
P356
10.1261/RNA.2375411
P407
P577
2010-11-23T00:00:00Z