Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence.
about
Mapping the HLA-DO/HLA-DM complex by FRET and mutagenesisHuman leukocyte Antigen-DM polymorphisms in autoimmune diseasesHLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanismClass II MHC self-antigen presentation in human B and T lymphocytesPathways of antigen processing.On the perils of poor editing: regulation of peptide loading by HLA-DQ and H2-A molecules associated with celiac disease and type 1 diabetes.H2-O, a MHC class II-like protein, sets a threshold for B-cell entry into germinal centers.The nonconventional MHC class II molecule DM governs diabetes susceptibility in NOD miceHLA-DO as the optimizer of epitope selection for MHC class II antigen presentation.Immunomodulation by gut microbiota: role of Toll-like receptor expressed by T cells.The mechanism of HLA-DM induced peptide exchange in the MHC class II antigen presentation pathwayGut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes.Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis.Mechanisms of peptide repertoire selection by HLA-DMMHC Class II Protein Turnover In vivo and Its Relevance for Autoimmunity in Non-Obese Diabetic Mice.Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes.The endosome-lysosome pathway and information generation in the immune system.Conformational variation in structures of classical and non-classical MHCII proteins and functional implications.HLA-DO and Its Role in MHC Class II Antigen Presentation.MHC class II antigen presentation by dendritic cells regulated through endosomal sorting.The lymph self-antigen repertoire.Inhibition of HLA-DM Mediated MHC Class II Peptide Loading by HLA-DO Promotes Self ToleranceHLA-DM and HLA-DO, key regulators of MHC-II processing and presentation.TLR agonists downregulate H2-O in CD8alpha- dendritic cells.Present Yourself! By MHC Class I and MHC Class II Molecules.Cutting edge: NADPH oxidase modulates MHC class II antigen presentation by B cells.Sibling rivalry: competition between MHC class II family members inhibits immunity.Identification of the major histocompatibility complex class-II DM and DO alleles in a cohort of northern pig-tailed macaques (Macaca leonina).Autoimmunity as a Driving Force of Cognitive Evolution.Negative selection in tumor genome evolution acts on essential cellular functions and the immunopeptidome.
P2860
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P2860
Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence.
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Targeted regulation of self-pe ...... ng general immunocompetence.
@ast
Targeted regulation of self-pe ...... ng general immunocompetence.
@en
type
label
Targeted regulation of self-pe ...... ng general immunocompetence.
@ast
Targeted regulation of self-pe ...... ng general immunocompetence.
@en
prefLabel
Targeted regulation of self-pe ...... ng general immunocompetence.
@ast
Targeted regulation of self-pe ...... ng general immunocompetence.
@en
P2093
P2860
P356
P1476
Targeted regulation of self-pe ...... ng general immunocompetence.
@en
P2093
Derek B Sant'Angelo
Kai W Wucherpfennig
Lisa K Denzin
Nilufer P Seth
Tom Martillotti
Woelsung Yi
P2860
P304
P356
10.1172/JCI40220
P407
P577
2010-04-01T00:00:00Z