NK1, a natural splice variant of hepatocyte growth factor/scatter factor, is a partial agonist in vivo

NK1, a natural splice variant of hepatocyte growth factor/scatter factor, is a partial agonist in vivo

Item
http://www.wikidata.org/entity/Q33772210
Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor.A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonistImmunohistochemical localization of hepatocyte growth factor activator (HGFA) in developing mouse liver tissues. Heterogeneous distribution of HGFA proteinNoncoding mutations of HGF are associated with nonsyndromic hearing loss, DFNB39.Disassociation of met-mediated biological responses in vivo: the natural hepatocyte growth factor/scatter factor splice variant NK2 antagonizes growth but facilitates metastasis.In vivo expression of HGF/NK1 and GLP-1 From dsAAV vectors enhances pancreatic ß-cell proliferation and improves pathology in the db/db mouse model of diabetes.Differential mitogenic effects of single chain hepatocyte growth factor (HGF)/scatter factor and HGF/NK1 following cleavage by factor Xa.Prenatal expression of MET receptor tyrosine kinase in the fetal mouse dorsal raphe nuclei and the visceral motor/sensory brainstemSF/HGF-c-Met autocrine and paracrine promote metastasis of hepatocellular carcinoma.Dissociation of heparan sulfate and receptor binding domains of hepatocyte growth factor reveals that heparan sulfate-c-met interaction facilitates signaling.An engineered dimeric fragment of hepatocyte growth factor is a potent c-MET agonist.The N-terminal domain of hepatocyte growth factor inhibits the angiogenic behavior of endothelial cells independently from binding to the c-met receptor.dsAAV8-mediated gene transfer and β-cell expression of IL-4 and β-cell growth factors are capable of reversing early-onset diabetes in NOD mice.CAR T-cell immunotherapy of MET-expressing malignant mesothelioma.Insights into the structure of hepatocyte growth factor/scatter factor (HGF/SF) and implications for receptor activation.Hepatocyte Growth Factor Isoforms in Tissue Repair, Cancer, and Fibrotic Remodeling.Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding
P2860

NK1, a natural splice variant of hepatocyte growth factor/scatter factor, is a partial agonist in vivo

Item
http://www.wikidata.org/entity/Q33772210
description
1998 nî lūn-bûn
@nan
1998 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մարտին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
NK1, a natural splice variant ...... , is a partial agonist in vivo
@ast
NK1, a natural splice variant ...... , is a partial agonist in vivo
@en
type
label
NK1, a natural splice variant ...... , is a partial agonist in vivo
@ast
NK1, a natural splice variant ...... , is a partial agonist in vivo
@en
prefLabel
NK1, a natural splice variant ...... , is a partial agonist in vivo
@ast
NK1, a natural splice variant ...... , is a partial agonist in vivo
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P932
P356
P1433
P1476
NK1, a natural splice variant ...... , is a partial agonist in vivo
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P932