Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor.
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Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptorTargeted disruption of heparan sulfate interaction with hepatocyte and vascular endothelial growth factors blocks normal and oncogenic signalingCrystal structure of the OpcA integral membrane adhesin from Neisseria meningitidisMET: a critical player in tumorigenesis and therapeutic targetCrystal structure of the TSP-1 type 1 repeatsA mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonistStructural and Functional Analysis of Slit and Heparin Binding to Immunoglobulin-like Domains 1 and 2 of Drosophila RoboNMR Solution Structure of the Neurotrypsin Kringle Domain † ‡Structural basis for agonism and antagonism of hepatocyte growth factorPAN-modular structure of microneme protein SML-2 from the parasite Sarcocystis muris at 1.95 Å resolution and its complex with 1-thio-β-D-galactoseGalactose Recognition by the Apicomplexan Parasite Toxoplasma gondiiFell-Muir Lecture: Heparan sulphate and the art of cell regulation: a polymer chain conducts the protein orchestra.DMT-MM mediated functionalisation of the non-reducing end of glycosaminoglycans.Structure of AMA1 from Plasmodium falciparum reveals a clustering of polymorphisms that surround a conserved hydrophobic pocket.Engineering hepatocyte growth factor fragments with high stability and activity as Met receptor agonists and antagonists.Coupling growth-factor engineering with nanotechnology for therapeutic angiogenesis.Functional map and domain structure of MET, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factorDocking server for the identification of heparin binding sites on proteins.BFMP: a method for discretizing and visualizing pyranose conformations.Differential mitogenic effects of single chain hepatocyte growth factor (HGF)/scatter factor and HGF/NK1 following cleavage by factor Xa.Heparin-binding domains in vascular biology.Extracellular angiogenic growth factor interactions: an angiogenesis interactome survey.Achieving high signal-to-noise in cell regulatory systems: Spatial organization of multiprotein transmembrane assemblies of FGFR and MET receptors.Adeno-associated virus-2 and its primary cellular receptor--Cryo-EM structure of a heparin complex.Targeting the MET oncogene in cancer and metastases.Hepatocyte growth factor/scatter factor binds to small heparin-derived oligosaccharides and stimulates the proliferation of human HaCaT keratinocytes.Mapping of heparin/heparan sulfate binding sites on αvβ3 integrin by molecular docking.The binding properties of minimal oligosaccharides reveal a common heparan sulfate/dermatan sulfate-binding site in hepatocyte growth factor/scatter factor that can accommodate a wide variety of sulfation patterns.Semi-synthesis of a HGF/SF kringle one (K1) domain scaffold generates a potent in vivo MET receptor agonist.Oligonucleotide-Based Mimetics of Hepatocyte Growth Factor.Thrombospondin-1 as a Paradigm for the Development of Antiangiogenic Agents Endowed with Multiple Mechanisms of Action.Interaction of hepatocyte growth factor with gelatin as the carrier material.Multiple biological responses are induced by glycosylation-deficient hepatocyte growth factorThiocarbamate-linked polysulfonate-peptide conjugates as selective hepatocyte growth factor receptor binders.An engineered dimeric fragment of hepatocyte growth factor is a potent c-MET agonist.Crystal structure of the factor XI zymogen reveals a pathway for transactivation.Zymogen activation of neurotrypsin and neurotrypsin-dependent agrin cleavage on the cell surface are enhanced by glycosaminoglycans.The N-terminal domain of hepatocyte growth factor inhibits the angiogenic behavior of endothelial cells independently from binding to the c-met receptor.Dissociation of c-Met phosphotyrosine sites in human cells in response to mouse hepatocyte growth factor but not human hepatocyte growth factor: the possible roles of different amino acids in different species.Interactions of hepatocyte growth factor/scatter factor with various glycosaminoglycans reveal an important interplay between the presence of iduronate and sulfate density.
P2860
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P2860
Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor.
description
2001 nî lūn-bûn
@nan
2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Crystal structures of NK1-hepa ...... t agonists of the MET receptor
@nl
Crystal structures of NK1-hepa ...... agonists of the MET receptor.
@ast
Crystal structures of NK1-hepa ...... agonists of the MET receptor.
@en
type
label
Crystal structures of NK1-hepa ...... t agonists of the MET receptor
@nl
Crystal structures of NK1-hepa ...... agonists of the MET receptor.
@ast
Crystal structures of NK1-hepa ...... agonists of the MET receptor.
@en
prefLabel
Crystal structures of NK1-hepa ...... t agonists of the MET receptor
@nl
Crystal structures of NK1-hepa ...... agonists of the MET receptor.
@ast
Crystal structures of NK1-hepa ...... agonists of the MET receptor.
@en
P2093
P2860
P356
P1433
P1476
Crystal structures of NK1-hepa ...... t agonists of the MET receptor
@en
P2093
D Y Chirgadze
E Gherardi
P2860
P304
P356
10.1093/EMBOJ/20.20.5543
P407
P577
2001-10-01T00:00:00Z