Previous estimates of mitochondrial DNA mutation level variance did not account for sampling error: comparing the mtDNA genetic bottleneck in mice and humans.
about
A wide range of 3243A>G/tRNALeu(UUR) (MELAS) mutation loads may segregate in offspring through the female germline bottleneck.Transmission of mitochondrial DNA diseases and ways to prevent them.The strength and timing of the mitochondrial bottleneck in salmon suggests a conserved mechanism in vertebrates.Very low-level heteroplasmy mtDNA variations are inherited in humansStochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism.Segregation of mtDNA throughout human embryofetal development: m.3243A>G as a model systemMaximizing signal-to-noise ratio in the random mutation capture assayRapid mitochondrial DNA segregation in primate preimplantation embryos precedes somatic and germline bottleneck.Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission.Universal heteroplasmy of human mitochondrial DNA.Mitochondrial DNA sequence characteristics modulate the size of the genetic bottleneckPreventing the transmission of pathogenic mitochondrial DNA mutations: Can we achieve long-term benefits from germ-line gene transfer?Mitochondrial DNA genetics and the heteroplasmy conundrum in evolution and disease.Evolution of Cell-to-Cell Variability in Stochastic, Controlled, Heteroplasmic mtDNA Populations.Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos.Mitochondrial biology in reproduction.Large-scale genetic analysis reveals mammalian mtDNA heteroplasmy dynamics and variance increase through lifetimes and generations.
P2860
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P2860
Previous estimates of mitochondrial DNA mutation level variance did not account for sampling error: comparing the mtDNA genetic bottleneck in mice and humans.
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Previous estimates of mitochon ...... bottleneck in mice and humans.
@ast
Previous estimates of mitochon ...... bottleneck in mice and humans.
@en
type
label
Previous estimates of mitochon ...... bottleneck in mice and humans.
@ast
Previous estimates of mitochon ...... bottleneck in mice and humans.
@en
prefLabel
Previous estimates of mitochon ...... bottleneck in mice and humans.
@ast
Previous estimates of mitochon ...... bottleneck in mice and humans.
@en
P2860
P1476
Previous estimates of mitochon ...... bottleneck in mice and humans.
@en
P2093
David C Samuels
Passorn Wonnapinij
P2860
P304
P356
10.1016/J.AJHG.2010.02.023
P407
P577
2010-04-01T00:00:00Z